靈敏、快速的內(nèi)皮素-1 ELISA試劑盒，適用于心血管和應(yīng)激相關(guān)研究
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內(nèi)皮素（Endothelin, ET）是由血管內(nèi)皮細(xì)胞產(chǎn)生的異肽，具有強(qiáng)大的血管收縮活性。這種肽由三個(gè)獨(dú)立的基因編碼，經(jīng)過(guò)加工產(chǎn)生39個(gè)殘基的 '大ET '分子，再進(jìn)一步加工成21個(gè)氨基酸序列，命名為ET-1、ET-2和ET-3。ET的作用是通過(guò)與兩個(gè)受體（ETA和ETB）的結(jié)合來(lái)介導(dǎo)的。ETA的激活會(huì)增加血管收縮和鈉潴留，從而增加血壓。ETB受體的激活引發(fā)血管舒張因子的釋放，如內(nèi)皮細(xì)胞的一氧化氮（NO）和前列腺素，并增加尿液的產(chǎn)生和排出，從而降低血壓。
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產(chǎn)品特點(diǎn)
◆ 高靈敏度，可檢測(cè)低至0.41pg/ml的ET-1，正常和病理樣本均可檢測(cè)
◆ 高通量，僅需2小時(shí)就能得到38份樣本（含復(fù)孔）的檢測(cè)結(jié)果
◆ 可靈活選擇過(guò)夜或1小時(shí)孵育
◆ 適用于多種樣本類型
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產(chǎn)品信息
產(chǎn)品貨號(hào) | ADI-900-020A |
產(chǎn)品名稱 | Endothelin-1 ELISA kit（內(nèi)皮素-1 ELISA試劑盒） |
規(guī)格 | 96 wells |
靈敏度 | 0.41 pg/ml |
檢測(cè)范圍 | 0.78 - 100 pg/ml |
應(yīng)用 | ELISA, Colorimetric detection |
適用樣本類型 | For the quantitative determination of ET-1 in culture supernatants, plasma,? and serum of human, mouse, rat, cow, dog, pig, and rabbit origin.? Cited sample types include cell lysates and tissue homogenates. |
檢測(cè)波長(zhǎng) | 450 nm |
適用種屬 | Human, Mouse, Rat Bovine, Dog, Porcine, Rabbit |
運(yùn)輸 | Blue Ice Not Frozen |
長(zhǎng)期保存 | +4°C |
試劑盒組分 | Microtiter plate, Antibody diluent, Antibody concentrate, Assay buffer 17,? Wash buffer concentrate, Standard, TMB Substrate, Stop solution 2 |
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標(biāo)準(zhǔn)曲線示例
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部分產(chǎn)品引用文獻(xiàn)
1.?NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption: O. Germande, et al.; Nanotoxicology 16, 29 (2022)
2.?Treatment with apocynin selectively restores hippocampal arteriole function and seizure-induced hyperemia in a model of preeclampsia: M.J. Cipolla, et al.; J. Cereb. Blood Flow Metab. (2022)
3.?Vasorin plays a critical role in vascular smooth muscle cells and arterial function: L. Louvet, et al.; J. Cell. Physiol. 237, 3845 (2022)
4.?Contributions of Sodium-Hydrogen Exchanger-1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes: Y.L. Chen, et al.; Diabetes 70, 2353 (2021)
5.?Dehulled Adlay Consumption Modulates Blood Pressure in Spontaneously Hypertensive Rats and Overweight and Obese Young Adults: W.-J. Jeh, et al.; Nutrients 13, 2305 (2021)
6.?Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial: T.V. Dam, et al.; Menopause 28, 1214 (2021)
7.?Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities: J. van de Wouw, et al.; Basic Res. Cardiol. 116, 51 (2021)
8.?Anthocyanin-Rich New Zealand Blackcurrant Extract Supports the Maintenance of Forearm Blood-Flow During Prolonged Sedentary Sitting: M.J. Barnes, et al.; Front. Nutr. 7, 74 (2020)
9.?Aerobic exercise training improves insulin-induced vasorelaxation in a vessel-specific manner in rats with insulin-treated experimental diabetes: M.W. McDonald, et al.; Diab. Vasc. Dis. Res. 16, 77 (2019)
10.?Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial: B. Chew, et al.; Eur. J. Nutr. 58, 1223 (2019)
11.?Gelatin-based perfusable, endothelial carotid artery model for the study of atherosclerosis: R. Chen, et al.; Biomed. Eng. Online 18, 87 (2019)
12.?Hyperglycemia enhances constriction of retinal venules via activation of the reverse-mode sodium-calcium exchanger: Y.L. Chen, et al.; Diabetes 68, 1624 (2019)
13.?In Vivo Comparative Study on Acute and Sub-acute Biological Effects Induced by Ultrafine Particles of Different Anthropogenic Sources in BALB/c Mice: F. Farina, et al.; Int. J. Mol. Sci. 20, 2805 (2019)
14.?Co-ingestion of whole eggs or egg whites with glucose protects against postprandial hyperglycaemia-induced oxidative stress and dysregulated arginine metabolism in association with improved vascular endothelial function in prediabetic men: J.D. McDonald, et al.; Br. J. Nutr. 120, 901 (2018)
15.?Effects of Personal Short-Term Exposure to Ambient Ozone on Blood Pressure and Vascular Endothelial Function: A Mechanistic Study Based on DNA Methylation and Metabolomics: Y. Xia, et al.; Environ. Sci. Technol. 52, 12774 (2018)
16.?Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells: H.C. Lin, et al.; Environ. Toxicol. 32, 918 (2017)
17.?Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats: A.M. Gad, et al.; J. Biochem. Mol. Toxicol. 31, (2017)
18.?Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt: A. Wannhoff, et al.; Aliment. Pharmacol. Ther. 43, 955 (2016)
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