首款上市的15-d-PGJ2 ELISA試劑盒，可用于類花生酸研究

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15-deoxy-Δ12,14-PGJ2（15-d-PGJ2）是PGD2的最終脫水產(chǎn)物之一，通過中間體Δ12-PGJ2形成。生理條件下，15-d-PGJ2存在于體液中，濃度介于10^(-12)至10^(-9)M，但在感染和炎癥等應激條件下會急劇增加。在細胞類型和濃度的影響下，15-d-PGJ發(fā)揮促進和抗炎癥作用，其中許多作用是通過與過氧化物酶體增殖劑激活受體（PPAR-γ）的γ異構(gòu)體結(jié)合而介導的。15-d-PGJ2似乎通過一種與PPAR-γ無關(guān)的機制誘導HO-1的表達，該機制由活性氧（ROS）的產(chǎn)生介導。

Enzo Life Sciences的15-脫氧-Δ12,14-前列腺素J2 ELISA試劑盒是一種比色競爭法酶聯(lián)免疫檢測試劑盒，可在5小時內(nèi)得到檢測結(jié)果，相比GC/MS 分析節(jié)省時間且耗時少得多。欣博盛生物作為Enzo Life Sciences授權(quán)中國一級代理，可提供該產(chǎn)品，歡迎咨詢。

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產(chǎn)品特色

◆ 靈敏度高，可測量低至36.8 pg/ml的15-deoxy-Δ12,14-PGJ2

◆?檢測快速，較GC/MS分析耗時少得多

◆?易于使用的即用型液體顏色編碼試劑，可減少錯誤

◆?優(yōu)于半定量Western blot分析的完全定量檢測

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產(chǎn)品信息

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標曲示例

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部分產(chǎn)品引用文獻

1.?Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia: L. Ra?ková, et al.; Toxicol. Appl. Pharmacol. 447, 116084 (2022)

2.?Fluoxetine‐induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15‐deoxy‐Δ12, 14PGJ2: A. Ayyash, et al.; J. Appl. Toxicol. 4272, 1002 (2021)

3.?Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis: C.D. Wiley, et al.; Cell Metab. 33, 1124 (2021)

4.?Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation: K. Brami-Cherrier, et al.; Nat. Commun. 11, 4448 (2020)

5.?Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway: Y. Zhang, et al.; FASEB J. 34, 11772 (2020)

6.?Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis: F. Desmarais, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 522 (2019)

7.?Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients: G. Oriolo, et al.; Brain Behav. Immun. 80, 204 (2019)

8.?Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis: Y.B. Kim, et al.; Cell. Mol. Immunol. 16, 851 (2019)

9.?Arachidonic acid induces ARE/Nrf2-dependent heme oxygenase-1 transcription in rat brain astrocytes: C.C. Lin, et al.; Mol. Neurobiol. 55, 3328 (2018)

10.?Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats: J. Zhou, et al.; J. Cell Mol. Med. 20, 1706 (2016)

11.?Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease: I. Kadiyska; (2016)

12.?CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis: M. Ishii, et al.; J. Immunol. 188, 5655 (2012)

13.?Choroidal involution is a key component of oxygen-induced retinopathy: Z. Shao, et al.; Invest. Ophthalmol. Vis. Sci. 52, 6238 (2011)

14.?Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1: P. Wang, et al.; FASEB J. 25, 3401 (2011)

15.?The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA: Y. Ye, et al.; Am. J. Physiol. Heart Circ. Physiol. 298, H1454 (2010)

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