BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28

2023-04-27

瀏覽次數(shù)： 43

BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28

產(chǎn)品描述：

BioXcell InVivoMab anti-mouse CD28 37.51單克隆抗體與小鼠CD28反應，CD28是一種45kDa的共刺激受體，也是Ig超家族的一員。CD28由胸腺細胞，大多數(shù)外周T細胞和NK細胞表達。CD28是CD80（B7-1）和CD86（B7-2）的受體。通過CD28的信號傳導增強了IL-2和IL-2受體的表達以及CD3活化的T細胞的細胞毒性。37.51抗體已被證明能刺激活化的T細胞和NK細胞的增殖和細胞因子的產(chǎn)生，并為CTL誘導提供共刺激信號。

BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28 ?

產(chǎn)品詳情：

產(chǎn)品名稱	InVivoMAb anti-mouse CD28
產(chǎn)品貨號	BE0015-1
產(chǎn)品規(guī)格	1/5/25/50/100mg
反應種屬	Mouse
克隆號	37.51
同種型	Syrian Hamster IgG2
免疫原	C57BL/6 mouse T cell lymphoma EL-4 cells
實驗應用	in vitro T cell stimulation/activation in vivo CD28 blockade
產(chǎn)品形式	PBS, pH 6.0 0.01% Tween,Contains no stabilizers or preservatives
純度	>95%, Determined by SDS-PAGE
無菌處理	0.2 μm filtration
純化方式	Protein G
RRID	AB_1107624
分子量	150 kDa
保存條件	抗體原液保存在4°C，不能冷凍保存。
推薦同型對照	InVivoMAb polyclonal Syrian hamster IgG（貨號BE0087）
推薦抗體稀釋液	InVivoPure pH 6.0T Dilution Buffer（貨號IPT060）

?該產(chǎn)品自上市已被多篇SCI文獻引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻引用：

應用

文章

體外T細胞刺激/激活

(in vitro T cell stimulation/activation)

1.?Lacher, S. M., et al. (2018). 'NF-kappaB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling' J Autoimmun 94: 110-121.

2.?Wendland, K., et al. (2018). 'Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis' J Immunol 201(2): 524-532.

3.?Ron-Harel, N., et al. (2016). 'Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation' Cell Metab 24(1): 104-117.

4.?Gu, A. D., et al. (2015). 'A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling' Immunity 42(1): 68-79.

5.?Choi, Y. S., et al. (2015). 'LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6' Nat Immunol 16(9): 980-990. ?

體內(nèi)CD28阻斷

(in vivo CD28 blockade)

1.?Rouhani, S. J., et al. (2015). 'Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction' Nat Commun 6: 6771.

2.?Eberlein, J., et al. (2012). 'Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity' J Virol 86(4): 1955-1970.

BioXcell熱銷產(chǎn)品--InVivoMab anti-mouse CD28