TLR3(又名CD283)是一個胞內(nèi)受體，可識別與病毒感染相關(guān)的雙鏈RNA(dsRNA)分子模式。其中一個TLR3的配體，Poly(I:C)，是人工合成的dsRNA類似物。TLR3信號通路不依賴于MyD88，而是通過接頭蛋白TRIF(包含TIR結(jié)構(gòu)域的接頭蛋白，可誘導(dǎo)IFN-β產(chǎn)生)發(fā)揮作用。IRF3(干擾素調(diào)節(jié)因子3)被磷酸化后導(dǎo)致IFN-β(β干擾素)產(chǎn)生，進(jìn)一步活化ISRE(干擾素激活反應(yīng)元件)。另外，TLR3信號通路的激活也可導(dǎo)致AP-1和NF-kB等轉(zhuǎn)錄因子入核，促進(jìn)一些炎癥因子的釋放。
TLR3激動劑相關(guān)產(chǎn)品：
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
TLR LIGANDS |
TLR3 Agonists |
Poly(A:U) | Polyadenylic-polyuridylic acid | TLR2 -/ TLR4 - | 300 ng- 100 μg/ml | 10 mg | tlrl-pau |
Poly(I:C) (HMW) | Polyinosine-polycytidylic acid High molecular weight (1.5-8 kb) | TLR2 -/ TLR4 - | 30 ng - 10 μg/ml | 10 mg 50 mg | tlrl-pic tlrl-pic-5 |
Poly(I:C) (HMW) Biotin | Biotinylated poly(I:C) (HMW) | TLR2 -/ TLR4 - | 30 ng - 10 μg/ml | 10 μg | tlrl-picb |
Poly(I:C) (HMW) Fluorescein | Fluorescein-labeled poly(I:C) (HMW) | TLR2 -/ TLR4 - | 10 ng - 10 μg/ml | 10 μg | tlrl-picf |
Poly(I:C) (HMW) Rhodamine | Rhodamine-labeled poly(I:C) (HMW) | TLR2 -/ TLR4 - | 10 ng - 10 μg/ml | 10 μg | tlrl-picr |
PRR Ligands
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
TLR3 Agonists |
Poly(I:C) (HMW) VacciGrade? | Preclinical grade? poly(I:C) (HMW) | VacciGrade? | 10 μg - 100 μg/mouse | 10 mg | vac-pic |
Poly(I:C) (LMW) | Polyinosine-polycytidylic acid Low molecular weight (0.2-1 kb) | TLR2 - /TLR4 - | 30 ng - 10 μg/ml | 25 mg 250 mg | tlrl-picw tlrl-picw-250 |
Poly(I:C) (LMW) Rhodamine | Rhodamine-labeled poly(I:C) (LMW) | TLR2 - /TLR4 - | 100 ng - 10 μg/ml | 10 μg | tlrl-piwr |
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