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BioXcell熱銷產(chǎn)品--InVivoPlus anti-mouse CD8α

2023-04-27
瀏覽次數(shù): 70

BioXcell熱銷產(chǎn)品--InVivoPlus anti-mouse CD8α

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產(chǎn)品描述:

BioXcell InVivoPlus anti-mouse CD8α克隆號YTS 169.4單克隆抗體能與小鼠CD8α反應(yīng)。CD8抗原是一種跨膜糖蛋白,作為T細胞受體的共受體。與TCR一樣,CD8與抗原呈遞細胞(APC)展示的I類MHC分子結(jié)合。CD8主要在細胞毒性T細胞表面表達,但也可在胸腺細胞、自然殺傷細胞和一些樹突狀細胞亞群中發(fā)現(xiàn)。CD8最常見的存在形式是由一個CD8α和一個CD8β鏈組成的異二聚體,然而,它也可以是由兩個CD8α鏈組成的同二聚體。CD8α和CD8β鏈均與免疫球蛋白可變輕鏈具有顯著同源性。每個CD8鏈的分子量約為34 kDa。BioXcell InVivoPlus anti-mouse CD8α克隆號YTS 169.4抗體在體內(nèi)使用時顯示出depleting活性。


BioXcell熱銷產(chǎn)品--InVivoPlus anti-mouse CD8α?

產(chǎn)品詳情:


產(chǎn)品名稱

InVivoPlus anti-mouse CD8α

產(chǎn)品貨號

BP0117

產(chǎn)品規(guī)格

5/25/50/100mg

反應(yīng)種屬

Mouse

克隆號

YTS 169.4

同種型

Rat IgG2b, κ

免疫原

CBA mouse thymocytes

實驗應(yīng)用

in vivo?CD8+ T cell depletion
Western blot

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無菌處理

0.2 μm filtration

純化方式

Protein G

RRID

AB_10950145

分子量

150 kDa

小鼠病原檢測

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C,不能冷凍保存。

推薦同型對照

InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin(貨號BP0090)

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer(貨號IP0070)



為什么選擇InVivoPlus抗體?

InVivoPlus級別的產(chǎn)品內(nèi)毒素含量更低,經(jīng)過多種實驗驗證,更適合用于體內(nèi)實驗研究

BioXcell熱銷產(chǎn)品--InVivoPlus anti-mouse CD8α


?該產(chǎn)品自上市已被多篇SCI文獻引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻引用:


應(yīng)用

文章

體內(nèi)CD8+T細胞耗竭

(in vivo CD8+ T cell depletion)

1.?Vashist, N., et al. (2018). 'Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression' Front Immunol 9: 505.

2.?Triplett, T. A., et al. (2018). 'Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme' Nat Biotechnol 36(8): 758-764.

3.?Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity' Nature 521(7550): 99-104.

4.?Burrack, K. S., et al. (2015). 'Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells' PLoS Pathog 11(10): e1005191.

5.?Wensveen, F. M., et al. (2015). 'NK cells link obesity-induced adipose stress to inflammation and insulin resistance' Nat Immunol 16(4): 376-385.

6.?Li, Z., et al. (2015). 'Pre-treatment of allogeneic bone marrow recipients with the CXCR4 antagonist AMD3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance' Transpl Immunol 33(2): 125-129.

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BioXcell熱銷產(chǎn)品--InVivoPlus anti-mouse CD8α

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