目前認(rèn)為 , 各種腦損傷 ( 腦缺氧、腦外傷 ) 的繼發(fā)性損傷或稱二次腦損傷 (secondary injury) 因素是造成腦損害發(fā)生、發(fā)展的重要原因。
這些因素涉及：腦缺氧、鈣離子超載、氧自由基堆積、炎性因子的刺激等。其中炎癥應(yīng)答 (inflammatory response) 是腦損傷病理生理過程中的一個重要組成環(huán)節(jié)，半胱氨酰白三烯 (cysteinyl LTs) 包括LTC4, LTD4 和 LTE4 是一類重要的炎癥反應(yīng)介質(zhì) , 是花生四烯酸 5-脂氧合酶 (5-lipoxygenase,5-LOX) 的代謝產(chǎn)物。 CysLTs 通過激活半胱氨酰白三烯受體 ( 包括 CysLT1 和 CysLT2 受體 ), 參與多種炎癥病理過程 , 介導(dǎo)平滑肌痙攣 (smooth muscle constriction) 、微血管滲漏 (vascular leak) 等。近年研究證明 , CysLTs 除在哮喘、過敏性鼻炎等炎癥性疾病發(fā)病過程中起重要作用外 , 也參與腦卒中、腦外傷、腦腫瘤、癲癇等中樞神經(jīng)系統(tǒng)疾病的病理生理過程。腦缺血后CysLTs 釋放增加 , 5-LOX 抑制劑能減少 CysLTs 的產(chǎn)生，從而保護腦缺血性損傷。
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更多產(chǎn)品詳情，請聯(lián)系Cayman一級代理商-欣博盛生物
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