LAG-3全稱為淋巴細(xì)胞活化基因3(Lymphocyte Activation Gene-3),又稱CD223,在T細(xì)胞活化的負(fù)調(diào)控以及穩(wěn)態(tài)增殖方面起重要作用。LAG-3與T細(xì)胞共受體CD4密切相關(guān),并與MHC II類分子結(jié)合,但結(jié)合MHCII比CD4具有更高親和力。LAG-3在腫瘤免疫治療方面存在巨大潛力。
產(chǎn)品詳情:
別名:Lymphocyte Activation Gene-3; FDC Protein; CD223
類型:Monoclonal Antibody
來源:Purified from concentrated hybridoma tissue culture supernatant.
應(yīng)用:ELISA
偶聯(lián):Biotin
克隆號:17B4
免疫原:Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.
同種型:Mouse IgG1kappa
濃度:1mg/ml
該產(chǎn)品自上市以來有多篇文獻(xiàn)引用,品質(zhì)有保證,以下是最新發(fā)表的文獻(xiàn)引用:
1.Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells: J. Bayry, et al.; J. Immunol. 178, 4184 (2007)
2.Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation: C. Casati, et al.; J. Immunol. 180, 3782 (2008)
訂購信息:
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