免疫穩(wěn)態(tài)失衡可以導(dǎo)致自身免疫疾病的發(fā)生。調(diào)節(jié)性T細(xì)胞(Tregs)是一種具有誘導(dǎo)和維持免疫耐受功能的T細(xì)胞亞群,在預(yù)防自身免疫疾病和維持免疫穩(wěn)態(tài)中起核心作用,可用于免疫穩(wěn)態(tài)失衡的治療。然而,在體內(nèi)使用非特異性Tregs治療自身免疫疾病可能增加患者全身免疫抑制的風(fēng)險,因此,誘導(dǎo)抗原特異性Tregs是疾病治療的最佳選擇。在利用Tregs建立新的免疫穩(wěn)態(tài)之前,首先應(yīng)清除過多的活化T細(xì)胞,打破已失衡的免疫狀態(tài)。以往研究通過輻射或使用抗體來破壞失衡的免疫響應(yīng),但此類方法存在很大的脫靶風(fēng)險,并可能導(dǎo)致免疫缺陷。此外,抗原特異性免疫耐受的有效誘導(dǎo)需要T細(xì)胞編程的精確協(xié)調(diào),這是很難實現(xiàn)的。
2021年3月11日,西安交通大學(xué)陳鑫教授團(tuán)隊與空軍軍醫(yī)大學(xué)金巖、劉世宇教授團(tuán)隊合作在Science Translational Medicine以封面形式發(fā)表了題為Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models 的文章。該研究成功構(gòu)建了一種通過清除活化T細(xì)胞誘導(dǎo)免疫耐受的多級微納材料,并基于模塊化設(shè)計,在不同自身免疫疾病模型中誘導(dǎo)抗原特異性Tregs,為自身免疫疾病的治療提供了新策略。
本文中使用了欣博盛ELISA試劑盒分別檢測了小鼠血清中TGF-β1, IL-17, IL-6和TNF-α等細(xì)胞因子的濃度以及小鼠脾細(xì)胞培養(yǎng)上清中IL-17, IL-6, TNF-α?和IFN-γ的濃度。
1.文章題目:Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models.
期 ???刊:Science Translational Medicine(影響因子:16.304)
發(fā)表時間:10 March 202
作 ???者:Chen X, Yang X, Yuan P, et al.
作者單位:西安交通大學(xué)
使用產(chǎn)品:Mouse TGF-β1, IL-17, IL-6, TNF-α and IFN-γ ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33692135/
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2.文章題目:Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
期 ???刊:Journal of extracellular vesicles(影響因子:14.976)
發(fā)表時間:10 March 2021
作 ???者:Gao X, Wang Y, Lu F, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院
使用產(chǎn)品:Mouse IL-6 and CRP ELISA Kit ????
https://pubmed.ncbi.nlm.nih.gov/33732415/
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3.文章題目:Sequential Release of Small Extracellular Vesicles from Bilayered Thiolated Alginate/Polyethylene Glycol Diacrylate Hydrogels for Scarless Wound Healing.
期 ???刊:ACS nano(影響因子:14.588)
發(fā)表時間:16 March 2021
作 ???者:Shen Y, Xu G, Huang H, et al.
作者單位:上海交通大學(xué)附屬第六人民醫(yī)院?
使用產(chǎn)品:Human?VEGF ELISA Kit ?
https://pubmed.ncbi.nlm.nih.gov/33723994/
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4.文章題目:Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation.
期 ???刊:Genome medicine(影響因子:10.675)
發(fā)表時間:26 March 2021
作 ???者:Han B, Jiang W, Cui P, et al.
作者單位:首都醫(yī)科大學(xué)宣武醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33771213/
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5.文章題目:T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance.
期 ???刊:Bioactive Materials(影響因子:8.724)
發(fā)表時間:10 March 2021
作 ???者:Yang X, Zhou F, Yuan P, et al.
作者單位:中國人民解放軍空軍軍醫(yī)大學(xué)
使用產(chǎn)品:Mouse TGF-β, IL-17, IL-6, IL-10, TNF-α and IFN-γ ELISA Kits ???
https://www.sciencedirect.com/science/article/pii/S2452199X21000943
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6.文章題目:Ion therapy of pulmonary fibrosis by inhalation of ionic solution derived from silicate bioceramics.
期 ???刊:Bioactive Materials(影響因子:8.724)
發(fā)表時間:10 March 2021
作 ???者:Chen T, Zhang Z, Weng D, et al.
作者單位:同濟大學(xué)附屬上海市肺科醫(yī)院
使用產(chǎn)品:Mouse TGF-β, IL-10,TNF-α, IL-6 and IL-1β ELISA Kits ???
https://www.sciencedirect.com/science/article/pii/S2452199X21000748
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7.文章題目:Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion.
期 ???刊:Cell Reports(影響因子:8.109)
發(fā)表時間:9 March 2021
作 ???者:Jiang J, Wang W, Sun F, et al.
作者單位:華東理工大學(xué)
使用產(chǎn)品:Mouse IL-1β ELISA Kit ??血清
https://pubmed.ncbi.nlm.nih.gov/33691113/
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8.文章題目:DJ-1 deficiency in hepatocytes improves liver ischemia-reperfusion injury by enhancing mitophagy.
期 ???刊:Cellular and Molecular Gastroenterology and Hepatology(影響因子:7.076)
發(fā)表時間:23 March 2021
作 ???者:Xu M, Hang H, Huang M, et al.
作者單位:上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院
使用產(chǎn)品:Mouse IL-6, TNF-α and IL-1β ELISA Kits ???
https://www.sciencedirect.com/science/article/pii/S2352345X2100059X
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9.文章題目:Interfering microRNA-410 Attenuates Atherosclerosis Via the HDAC1/KLF5/IKBα/NF-κB Axis.
期 ???刊:Molecular Therapy-Nucleic Acids(影響因子:7.032)
發(fā)表時間:13 March 2021
作 ???者:Nan S, Wang Y, Xu C, et al.
作者單位:吉林大學(xué)第二醫(yī)院
使用產(chǎn)品:Human IL-6 ELISA Kit
https://www.sciencedirect.com/science/article/pii/S2162253121000809
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10.文章題目:Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency.
期 ???刊:Journal of biomedical science(影響因子:5.762)
發(fā)表時間:15 March 2021
作 ???者:Tang X, Wang W, Hong G, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33722220/
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11.文章題目:Phase-Transformation Nanoparticle-Mediated Sonodynamic Therapy: An Effective Modality to Enhance Anti-Tumor Immune Response by Inducing Immunogenic Cell Death in Breast Cancer.
期 ???刊:International Journal of Nanomedicine(影響因子:5.115)
發(fā)表時間:5 March 2021
作 ???者:Si Y, Yue J, Liu Z, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院
使用產(chǎn)品:Mouse IFN-γ ELISA Kit???????
https://pubmed.ncbi.nlm.nih.gov/33707946/
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12.文章題目:The BCMA-Targeted Fourth-Generation CAR-T Cells Secreting IL-7 and CCL19 for Therapy of Refractory/Recurrent Multiple Myeloma.
期 ???刊:Frontiers in Immunology(影響因子:5.085)
發(fā)表時間:5 March 2021
作 ???者:Duan D, Wang K, Wei C, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Human CCL19/MIP-3β ELISA Kit ???
https://pubmed.ncbi.nlm.nih.gov/33767695/
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13.文章題目:ZBTB20 Positively Regulates Oxidative Stress, Mitochondrial Fission, and Inflammatory Responses of ox-LDL-Induced Macrophages in Atherosclerosis.
期 ???刊:Oxidative Medicine and Cellular Longevity(影響因子:5.076)
發(fā)表時間:11 March 2021
作 ???者:Tao J, Qiu J, Lu L, et al.
作者單位:中山大學(xué)孫逸仙紀(jì)念醫(yī)院?
使用產(chǎn)品:Mouse TNF-α, IL-6 and IFN-β ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33777314/
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14.文章題目:Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis.
期 ???刊:Oxidative Medicine and Cellular Longevity(影響因子:5.076)
發(fā)表時間:16 March 2021
作 ???者:Zha Z, Gao Y F, Ji J, et al.
作者單位:首都醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6 and IL-10 ELISA Kits
樣本類型:大腦和脊髓組織
https://www.hindawi.com/journals/omcl/2021/5521503/
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15.文章題目:BACH2-mediated FOS confers cytarabine resistance via stromal microenvironment alterations in pediatric ALL.
期 ???刊:Cancer science(影響因子:4.966)
發(fā)表時間:March 2021
作 ???者:Zhang H, Zhang R, Zheng X, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院醫(yī)學(xué)生物學(xué)研究所
使用產(chǎn)品:Human IL-6 and IL-8 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33393145/
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16.文章題目:Fabrication of ulcer-adhesive oral keratin hydrogel for gastric ulcer healing in a rat.
期 ???刊:Regenerative Biomaterials(影響因子:4.882)?
發(fā)表時間:13 March 2021
作 ???者:Cheng Z, Qing R, Hao S, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Rat IL-6 ELISA Kit
樣本類型:胃組織
https://pubmed.ncbi.nlm.nih.gov/33738122/
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17.文章題目:MicroRNA-18b-5p Downregulation Favors Mycobacterium tuberculosis Clearance in Macrophages via HIF-1α by Promoting an Inflammatory Response.
期 ???刊:ACS Infectious Diseases(影響因子:4.614)
發(fā)表時間:11 March 2021
作 ???者:Zhu T, Liu H, Su L, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-6 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/33705114/
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18.文章題目:In vitro and in vivo assessments of Artemisia argyi fermented with Lactobacillus plantarum WLPL01 as an alternative anti-Salmonella agent.
期 ???刊:Food Control(影響因子:4.258)
發(fā)表時間:15 March 2021
作 ???者:Tao X, Tian L, Zhan H, et al.
作者單位:南昌大學(xué)
使用產(chǎn)品:Mouse IL-1β, TNF-α and IFN-γ ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0956713521002176
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19.文章題目:Burn ointment promotes cutaneous wound healing by modulating the PI3K/AKT/mTOR signaling pathway.
期 ???刊:Frontiers in Pharmacology(影響因子:4.225)
發(fā)表時間:8 March 2021
作 ???者:Gan D, Su Q, Su H, et al.
作者單位:中南民族大學(xué)?
使用產(chǎn)品:Rat TNF-α, VEGF and TGF-β1 ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33762951/
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20.文章題目:Lipopolysaccharide Preparation Derived From Porphyromonas gingivalis Induces a Weaker Immuno-Inflammatory Response in BV-2 Microglial Cells Than Escherichia coli by Differentially Activating TLR2/4-Mediated NF-κB/STAT3 Signaling Pathways.
期 ???刊:Frontiers in Cellular and Infection Microbiology(影響因子:4.123)
發(fā)表時間:18 March 2021
作 ???者:Qiu C, Yuan Z, He Z, et al.
作者單位:上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6, TNF-α and IL-23 ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33816329/
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21.文章題目:Escherichia coli Heat-Labile Enterotoxin B Subunit Combined with Ginsenoside Rg1 As an Intranasal Adjuvant Triggers Type I Interferon Signaling Pathway and Enhances Adaptive Immune Responses to an Inactivated PRRSV Vaccine in ICR Mice.
期 ???刊:Vaccines(影響因子:4.086)
發(fā)表時間:16 March 2021
作 ???者:Su F, Wu Y, Li J, et al.
作者單位:浙江省農(nóng)業(yè)科學(xué)院畜牧獸醫(yī)研究所
使用產(chǎn)品:Mouse?IFN-γ, IL-2, IL-5, IL-10, IL-6 and IL-17A ELISA Kits??
https://pubmed.ncbi.nlm.nih.gov/33809809/
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22.文章題目:SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway.
期 ???刊:Life Sciences(影響因子:3.647)?
發(fā)表時間:1 March 2021
作 ???者:Luo Y, Huang Z, Mou T, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Mouse?IL-18 and IL-1β ELISA Kits????????
https://pubmed.ncbi.nlm.nih.gov/33662429/
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23.文章題目:P4HA1 Down-Regulation Inhibits Glioma Invasiveness by Promoting M1 Microglia Polarization.
期 ???刊:OncoTargets and therapy(影響因子:3.337)
發(fā)表時間:8 March 2021
作 ???者:Wang Q, Zhang J, Fang S, et al.
作者單位:首都醫(yī)科大學(xué)附屬北京天壇醫(yī)院
使用產(chǎn)品:Goat anti-rabbit and goat anti-mouse IgG antibodies (HRP)
https://pubmed.ncbi.nlm.nih.gov/33727827/
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24.文章題目:Inhibition of endotoxin-induced acute lung injury in rats by bone marrow–derived mesenchymal stem cells: Role of Nrf2/HO-1 signal axis in inhibition of NLRP3 activation.
期 ???刊:Biochemical and Biophysical Research Communications(影響因子:2.985)
發(fā)表時間:10 March 2021
作 ???者:Lei L, Guo Y, Lin J, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Rat IL-1β, IL-6 and TNF-α ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/33713981/
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25.文章題目:Dexmedetomidine attenuates lipopolysaccharide-induced acute liver injury in rats by inhibiting caveolin-1 downstream signaling pathway.
期 ???刊:Bioscience Reports(影響因子:2.942)
發(fā)表時間:4 March 2021
作 ???者:Tong F, Shen W, Song P, et al.
作者單位:湖州市中心醫(yī)院
使用產(chǎn)品:Rat?IL-1β and IL-18 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33558888/
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26.文章題目:Long-chain non-coding RNA-GAS5/hsa-miR-138-5p attenuates high glucose-induced cardiomyocyte damage by targeting CYP11B2.
期 ???刊:Bioscience Reports(影響因子:2.942)
發(fā)表時間:8 March 2021
作 ???者:Zhuo X Z, Bai K, Wang Y, et al.
作者單位:西安交通大學(xué)第一附屬醫(yī)院?
使用產(chǎn)品:Mouse IL-1β ELISA Kit ????
https://pubmed.ncbi.nlm.nih.gov/33682891/
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27.文章題目:Outer membrane vesicles derived from hypervirulent Klebsiella pneumoniae stimulate the inflammatory response.
期 ???刊:Microbial Pathogenesis(影響因子:2.914)?
發(fā)表時間:7 March 2021
作 ???者:Zhang J, Zhao J, Li J, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Human IL-6, IL-8, IL-1β and mouse IL-6, IL-8 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33691173/
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28.文章題目:Immunity improvement and gut microbiota remodeling of mice by wheat germ globulin.
期 ???刊:World Journal of Microbiology and Biotechnology(影響因子:2.477)
發(fā)表時間:18 March 2021
作 ???者:Yu G, Ji X, Huang J, et al.
作者單位:河南工業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, IL-10, TNF-α, IFN-γ, IgG, IgA and IgM ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33733383/
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29.文章題目:Low-molecular-weight heparin calcium attenuates the tourniquet-induced ischemia-reperfusion injury in rats.
期 ???刊:Injury(影響因子:2.106)
發(fā)表時間:5 March 2021
作 ???者:He J, He L, Lu F, et al.
作者單位:蘭州大學(xué)第二醫(yī)院
使用產(chǎn)品:Rat IL-1β and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33726921/
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30.文章題目:The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice.
期 ???刊:Experimental Animals(影響因子:1.574)
發(fā)表時間:8 March 2021
作 ???者:Zhou D, Yang F, Lin L, et al.
作者單位:重慶市涪陵中心醫(yī)院
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33678756/
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