The Dengue virus (DEN) is of the genus Flavivirus and possesses a positive-strand RNA genome of approximately 10.6 kb that contains a single open-reading frame encoding for a polyprotein， which can be further cleaved by cellular and viral proteases into three structural proteins (capsid protein C, membrane protein M, envelope protein E), and seven non-structural proteins (NS 1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). There are four serotypes (DEN 1-4), though there is certainly genotypic variability in individual viral genomes within each serotype. This variability is thought to have minimal clinical significance , as human infection from any of the four serotypes results in long-term immunity to that serotype . However, cross-immunity between serotypes is of much shorter duration , meaning that many people are victims of sequential infection by different serotypes. This is clinically very important, as sequential infection appears to be a risk?factor for more serious disease manifestations.
登革熱病毒抗體推薦
Dengue Virus Protein Schematic Diagram (Non-Structural Proteins (Orange)
Dengue virus 1, 2, 3 & 4 antibody [D1-11 (3)] (GTX29202) ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?NS1 (Dengue virus ) antibody [GT1 061] (GTX630SS7)Dengue virus antibody detects Dengue virus 1 protein at ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? NS1 antibody detects NS1 (Dengue virus) protein at?
cytoplasm by immunofluorescent analysis ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?cytoplasm?by immunofluorescent analysis
Envelope protein (Dengue virus) antibody [GT214] (GTX629116) ? ? ? ? ? ? ? ? ? WB analysis for all blots
Envelope protein antibody detects Envelope protein (Dengue ? ? ? ? ? ? ? ? ? ? ? ? A: BHK-21; B: DEN2-infecled BHK-21; C: JEV-infecled BHK
virus) protein at cytoplasm by immunofluorescent analysis ? ? ? ? ? ? ? ? ? ? ? ? ? ??-21?Blols probed wilh Rb pAb 10 (Ieft 10 righl): NS1 (GTX124
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 280);?NS2B (GTX124246); NS3 (GTX124252); NS4B (GTX124
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ??250);?NS5 (GTX124253)
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?Cat.NO | ?Product | ?Reactivity | ?Host&Clonality | ?Application |
GTX29202 | Dengue Virus 1, 2, 3 & 4 antibody [D1-11(3)] | DEN | Ms mAb IgG2a | Dot blot, ELlSA, ICC/IF, WB |
GTX41428 | ?Dengue Virus Type 2 antibody [NYRDeng2] | DEN2 | Ms mAb IgG1 | ELISA. WB |
GTX43295 | ?Dengue Types 1,2,3,4 antibody [BDI419] | DEN | Ms mAb IgG2a | Dot blot, ELlSA, ICC川F |
GTX41437 | ?Dengue Virus antibody [5161] | DEN | Ms mAb IgG2a | ELISA |
GTX41430? | ?Dengue Virus Type 2 antibody [3H5.1] | DEN2 | Ms mAb IgG1 | ICC/IF |
GTX43296 | ?Dengue Type 2, envelope antibody [B932M] | DEN2 | Ms mAb IgG1 | ICC/IF |
GTX124247 | Capsid Protein (Dengue Virus) antibody | Capsid (DEN) | Rb pAb | WB |
GTX103343 | Capsid Protein (Dengue Virus) antibody | Capsid (DEN) | Rb pAb | ICC/IF. WB |
GTX128092 | PrM (Dengue Virus) antibody | PrM (DEN) | Rb pAb | WB |
GTX128093 | PrM (Dengue Virus) antibody | PrM (DEN) | Rb pAb | WB |
GTX127277 | Envelope protein (Dengue Virus) antibody | Envelope (DEN) | Rb pAb | ICC/IF. WB |
GTX629116 | Envelope protein (Dengue Virus) antibody [GT214] | Envelope (DEN) | Ms mAb IgG2a | ICC/IF. WB |
GTX629117 | Envelope protein (Dengue Virus) antibody [GT643] | Envelope (DEN) | Ms mAb IgG2b | ICC/IF. WB |
GTX630557 | NS1 (Dengue virus) antibody [GT1061] | NS1 (DEN) | Ms mAb IgG1(NEW Producr) | ICC/IF. WB |
GTX630556 | NS1 (Dengue virus) antibody [GT4212] | NS1 (DEN) | Ms mAb IgG2a(NEW Producr) | ICC/IF. WB |
GTX103346 | NS1 (Dengue Virus 2) antibody | NS1 (DEN2) | Rb pAb | ICC/IF. WB |
GTX124280 | NS1 (Dengue Virus) antibody | NS1 (DEN) | Rb pAb | ICC/IF. WB |
GTX124246 | NS2B (Dengue Virus) antibody | NS2B (DEN) | Rb pAb | ICC/IF. WB |
GTX124252 | NS3 (Dengue Virus) antibody | NS3 (DEN) | Rb pAb | ICC/IF. WB |
GTX629477 | NS3 (Dengue Virus) antibody [GT2811] | NS3 (DEN) | Ms mAb IgG1 | ICC/IF. WB |
GTX124249 | NS4A (Dengue Virus) antibody | NS4A (DEN) | Rb pAb | WB |
GTX103349 | NS4B (Dengue Virus) antibody | NS4B (DEN) | Rb pAb | ICC/IF. WB |
GTX124250 | NS4B (Dengue Virus) antibody | NS4B (DEN) | Rb pAb | ICC/IF. WB |
GTX103350 | NS5 (Dengue Virus) antibody | NS5 (DEN) | Rb pAb | ICC/IF. WB |
GTX124253 | NS5 (Dengue Virus) antibody | NS5 (DEN) | Rb pAb | ICC/IF. WB |
GTX629446 | NS5 (Dengue Virus 2) antibody [GT353] | NS5 (DEN) | Ms mAb IgG2b | ICC/IF. WB |
GTX629447 | NS5 (Dengue Virus 2) antibody [GT361] | NS5 (DEN) | Ms mAb IgG1 | ICC/IF. WB |
Dengue?infections?are?caused?by?four?closely?related?viruses?named?DEN-1,?DEN-2,?DEN-3,?and?DEN-4.?These?four?viruses?are?called
serotypes.?All?four?dengue?serotypes?circulate?together?in?tropical?and?subtropical?regions?around?the?world.
The?Viral?genome?is?translated?as?a?single,?long?polypeptide?and?then?cut?into?ten?proteins.
Three?are?structural?proteins:?the?capsid?(C),?envelope?(E),?and?membrane?(M)?proteins.?Seven?are?nonstructural?proteins:?NS1,?NS2A,?
NS2B,?NS3,?NS4A,?NS4B,?and?NS5.?These?nonstructural?proteins?play?roles?in?viral?replication?and?assembly.
| ?Proteins | ?Functions | ?GeneTex?Antibodies |
?Structure ?
?Proteins | ?Capsid | ?Encapsidation?of?the?RNA?genome.?May?regulate?host?
?cell?apoptosis?through?stabilizing?P53 | ?GTX124247,?GTX103343 |
| ?Envelope | ?Allowing?virus?to?enter?host?cells.?Essential?target?of ?
?antiviral?vaccine?★.? | ?GTX43296 |
| ?Membrane | ?Compose?viral?membrane?structure | ?GTX127277,?GTX629116,?
?GTX629117, |
?Non-Structure ?
?Proteins | ?NS1 | ?Essential?for?virus?replication,?as?a?target?of?humural?
?immunity. | ?GTX630556,
?GTX630557,?GTX103346, ? ?
?GTX124280, |
| ?NS2A,?2B | ?Viral?RNA?synthesis,?virion?assembly/maturation,?and?
?antagonizes?the?host?immune?response | ?GTX124246?(2B) |
| ?NS3 | ?Protease/?nucleotide?triphosphatases?and?helicase ?
?activity?used?for?viral?RNA?synthesis.? | ?GTX124252,?GTX629477, |
| ?NS4A,?4B | ?Blocking?IFNa/b?signaling?and?involved?in?STAT?pathway ?
?in?host?cells. | ?GTX124249?(4A),?GTX103349?(4B),?
?GTX124250?(4B) |
| ?NS5 | ?Viral?RNA?polymerase?and?methyltransferase.? | ?GTX103350,?GTX124253, ?
?GTX629446,?GTX629447 |
?GeneTex?Antibodies?against?whole?
?virons | ?GTX29202,?GTX41428,?GTX43295,?GTX41437,?GTX41430 |