近期,中國醫(yī)學科學院皮膚病研究所姚煦教授團隊、復旦大學附屬華山醫(yī)院李巍教授團隊及香港城市大學董立新教授團隊合作在 Cell Host & Microbe(IF=20.6)上發(fā)表題為“Multi-omics Signatures Reveal Genomic and Functional Heterogeneity of Cutibacterium acnes in Normal and Diseased Skin.”(多組學特征揭示正常和患病皮膚中痤瘡丙酸桿菌的基因組和功能異質性)的研究,在該項目中,研究團隊從1234個分離基因組中證明了C. acnes的個體和生態(tài)位異質性。皮膚疾病(濕疹和痤瘡)和身體部位決定了C. acnes的基因組差異,這種差異源于水平基因轉移和選擇壓力。與表皮葡萄球菌(Staphylococcus epidermidis)相比,C. acnes具有獨特的代謝功能,抗生素耐藥基因和毒力因子較少,基因組更穩(wěn)定。綜合基因組、轉錄組和代謝組分析在菌株水平揭示了C. acnes的功能特征。與轉錄組特征一致,C. acnes在富含皮脂的環(huán)境中對角質形成細胞產(chǎn)生毒性和促炎作用。L-肌肽(L-carnosine)是一種抗氧化應激代謝物,在濕疹的代謝組中上調并減輕皮膚炎癥。總的來說,該研究揭示了基因和微環(huán)境對C. acnes功能的共同影響。利用從健康皮膚、濕疹(AD)和痤瘡患者皮膚分離的痤瘡丙酸桿菌(Cutibacterium acnes, C. acnes)菌株進行了全基因組測序、轉錄組測序、代謝組測序以及功能研究,研究團隊首次從單菌株層面揭示了C. acnes的基因和功能異質性。通過深入地了解宿主和皮膚微生物群之間的復雜關系,有望能找到增進皮膚健康和改善皮膚病管理的靶點,也為將來探索C. acnes的臨床應用奠定了基礎。
該項研究中,使用了欣博盛生物(NeoBioscience Technology Co, Ltd)的 Mouse IgE, IL-4, IL-6, IL-13 and IL-33 ELISA Kits,用于檢測小鼠血樣中相關指標的含量。
貨號 | 產(chǎn)品名稱 | 靈敏度 | 檢測范圍 |
EMC117 | QuantiCyto??Mouse IgE ELISA Kit(小鼠免疫球蛋白E) | 0.78ng/ml | 1.56-100ng/ml |
EMC003 | QuantiCyto??Mouse IL-4 ELISA kit(小鼠白細胞介素-4) | 3.9pg/ml | 7.8-500pg/ml |
EMC004 | QuantiCyto??Mouse IL-6 ELISA kit(小鼠白細胞介素-6) | 7.8pg/ml | 15.6-1000pg/ml |
EMC124 | QuantiCyto??Mouse IL-13 ELISA kit(小鼠白細胞介素-13) | 2.344 pg/ml | 4.688-300pg/ml |
EMC110 | QuantiCyto??Mouse IL-33 ELISA kit(小鼠白細胞介素-33) | 23.44pg/ml | 46.875-3000pg/ml |
欣博盛生物非常榮幸能夠作為供應商為該項研究提供高品質ELISA試劑盒,為生物醫(yī)學領域的科研探索貢獻一份力量。
1.?Multi-omics signatures reveal genomic and functional heterogeneity of Cutibacterium acnes in normal and diseased skin.(Cell Host & Microbe, IF=20.6)
發(fā)表時間:2024/6/26
作者:Yu T, Xu X, Liu Y, et al.
作者單位:復旦大學附屬華山醫(yī)院
使用產(chǎn)品:Mouse IgE, IL-4, IL-6, IL-13 and IL-33 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38936370/
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2.?Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion.(ACS nano, IF=15.8)
發(fā)表時間:2024/6/4
作者:Wang B, Tang M, Chen Q, et al.
作者單位:上海交通大學
使用產(chǎn)品:Mouse IL-12, IL-2, TNF-α and IFN-γ ELISA Kits
樣本類型:腫瘤組織
https://pubmed.ncbi.nlm.nih.gov/38832815/
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3.?Nonswellable Hydrogel Patch with Tissue-Mimetic Mechanical Characteristics Remodeling In Vivo Microenvironment for Effective Adhesion Prevention.(ACS nano, IF=15.8)
發(fā)表時間:2024/6/27
作者:Liu X, Qiu X, Nie L, et al.
作者單位:重慶大學
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits
樣本類型:條件培養(yǎng)基
https://pubmed.ncbi.nlm.nih.gov/38932673/
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4.?Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses.(Acta Pharmaceutica Sinica B, IF=14.7)
發(fā)表時間:2024/6/20
作者:Yin L, Zhang E, Mao T, et al.
作者單位:中國藥科大學
使用產(chǎn)品:Mouse IL-27 and IFN-γ ELISA Kits
https://www.sciencedirect.com/science/article/pii/S2211383524002399
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5.?Choroid plexus CCL2?CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.(Acta Pharmaceutica Sinica B, IF=14.7)
發(fā)表時間:2024/6/26
作者:Wang Q, Liu F, Li Y, et al.
作者單位:四川大學華西醫(yī)院
使用產(chǎn)品:Rat CCL2, TNF-α and IL-1β ELISA Kits
樣本類型:腦脊液
https://www.sciencedirect.com/science/article/pii/S221138352400251X
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6.?PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma.(Nature Communications, IF=14.7)
發(fā)表時間:2024/6/21
作者:Huang S Y, Gong S, Zhao Y, et al.
作者單位:中山大學腫瘤防治中心
使用產(chǎn)品:Mouse IL-1α, IL-6 and CXCL10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38906860/
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7.?Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer.(Nature Communications, IF=14.7)
發(fā)表時間:2024/6/17
作者:Bai H, Liu X, Lin M, et al.
作者單位:西湖大學
使用產(chǎn)品:Histostain-Plus IHC Kit
https://pubmed.ncbi.nlm.nih.gov/38886378/
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8.?T Cell-Derived Apoptotic Extracellular Vesicles Hydrolyze cGAMP to Alleviate Radiation Enteritis via Surface Enzyme ENPP1.(Advanced Science, IF=14.3)
發(fā)表時間:2024/6/18
作者:Zhou Y, Bao L, Gong S, et al.
作者單位:西北大學
使用產(chǎn)品:Mouse IL-10 and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38888507/
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9.?Reversing MET-Mediated Resistance in Oncogene-Driven NSCLC by MET-Activated Wnt Condensative Prodrug.(Advanced Science, IF=14.3)
發(fā)表時間:2024/6/13
作者:Liu N, Zheng X, Yan J, et al.
作者單位:西安交通大學第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-2, IL-6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38867713/
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10.?Chemical conjugation mitigates immunotoxicity of chemotherapy via reducing receptor-mediated drug leakage from lipid nanoparticles.(Science Advances, IF=11.7)
發(fā)表時間:2024/6/5
作者:Zheng C, Zhang W, Gong X, et al.
作者單位:中國科學院上海藥物研究所
使用產(chǎn)品:Mouse TNF-α, IFN-γ, and IL-12p40 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38838152/
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11.?Pulmonary fibroblast-specific delivery of siRNA exploiting exosomes-based nanoscaffolds for IPF treatment.(Asian Journal of Pharmaceutical Sciences, IF=10.7)
發(fā)表時間:2024/6/11
作者:Lu H, Liu X, Zhang M, et al.
作者單位:沈陽藥科大學
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits
樣本類型:支氣管灌洗液
https://www.sciencedirect.com/science/article/pii/S1818087624000461
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12.?CircMALAT1 promotes cancer stem-like properties and chemoresistance via regulating Musashi-2/c-Myc axis in esophageal squamous cell carcinoma.(MedComm, IF=10.7)
發(fā)表時間:2024/6/14
作者:Zhao Z, Deng Y, Han J, et al.
作者單位:中國醫(yī)學科學院腫瘤醫(yī)院
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/38881674/
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13.?EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion.(Journal for ImmunoTherapy of Cancer, IF=10.3)
發(fā)表時間:2024/6/17
作者:Chen Y, Ouyang D, Wang Y, et al.
作者單位:中山大學腫瘤中心
使用產(chǎn)品:Human CXCL10, CSF1, IL-10 and MMP-9 ELISA Kits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11184188/
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14.?Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice.(Journal of Neuroinflammation, IF=9.3)
發(fā)表時間:2024/7/25
作者:He Y, Zhao J, Ma Y, et al.
作者單位:上海市靜安區(qū)中心醫(yī)院
使用產(chǎn)品:Mouse IL-6 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/38849869/
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15.?Fabrication of chitosan-based emulsion as an adjuvant to enhance nasal mucosal immune responses.(International Journal of Biological Macromolecules, IF=7.7)
發(fā)表時間:2024/6/6
作者:Li D, Li W, Li S, et al.
作者單位:華中農(nóng)業(yè)大學
使用產(chǎn)品:Mouse IFN-γ and IL-4 ELISA Kits
樣本類型:脾臟組織
https://pubmed.ncbi.nlm.nih.gov/38851606/
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16.?Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival.(Chinese Medical Journal, IF=7.5)
發(fā)表時間:2024/5/31
作者:Yuan W, Zhang H, Peng L, et al.
作者單位:中南大學湘雅第二醫(yī)院
使用產(chǎn)品:Mouse IFN-γ, IL-1β, IL-10 and IL-17 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38811343/
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17.?Artemisinin attenuated ischemic stroke induced pyroptosis by inhibiting ROS/TXNIP/NLRP3/Caspase-1 signaling pathway.(Biomedicine & Pharmacotherapy, IF=6.9)
發(fā)表時間:2024/6/14
作者:Wang Y, Yuan H, Shen D, et al.
作者單位:浙江中醫(yī)藥大學
使用產(chǎn)品:Mouse IL-1β and IL-18 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38878634/
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18.?Chemopreventive effects of atractylenolide-III on mammary tumorigenesis via activation of the Nrf2/ARE pathway through autophagic degradation of Keap1.(Biomedicine & Pharmacotherapy, IF=6.9)
發(fā)表時間:2024/6/3
作者:Long F, Wang P, Ma Y, et al.
作者單位:成都醫(yī)學院
使用產(chǎn)品:Rat TNF-α, IL-6 and IL-1β ELISA Kits
樣本類型:乳腺組織
https://pubmed.ncbi.nlm.nih.gov/38834007/
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19.?DHTPY-Cu@ZOL-Enhanced Photodynamic Therapy: A Strategic Platform for Advanced Treatment of Drug-Resistant Bacterial Wound Infections.(International Journal of Nanomedicine, IF=6.6)
發(fā)表時間:2024/6/21
作者:Hou B, Li B, Deng W, et al.
作者單位:南方醫(yī)科大學第三附屬醫(yī)院
使用產(chǎn)品:Rat TGF-β1 and IL-6 ELISA Kits
樣本類型:組織樣本
https://pubmed.ncbi.nlm.nih.gov/38919773/
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20.?Nerve growth factor alleviates arsenic-induced testicular injury by enhancing the function of Sertoli cells.(Ecotoxicology and Environmental Safety, IF=6.2)
發(fā)表時間:2024/6/10
作者:Yang Y, Hong Y, Han J, et al.
作者單位:貴州醫(yī)科大學
使用產(chǎn)品:Goat Anti-Rabbit IgG secondary antibody
https://pubmed.ncbi.nlm.nih.gov/38861803/
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21.?Bifidobacterium adolescentis-derived hypaphorine alleviates acetaminophen hepatotoxicity by promoting hepatic Cry1 expression.(Journal of Translational Medicine, IF=6.1)
發(fā)表時間:2024/5/31
作者:Qin P, Li Y, Su Y, et al.
作者單位:廣東藥科大學
使用產(chǎn)品:Mouse TNF-α, IL-6 and MCP-1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38822329/
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22.?β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.(Chinese Medicine, IF=5.3)
發(fā)表時間:2024/6/15
作者:Zhao Q, Chen L, Zhang X, et al.
作者單位:中國藥科大學
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38879549/
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23.?Human amniotic epithelial stem cell-derived dopaminergic neuron-like cells ameliorate motor dysfunction in a rat model of Parkinson's disease.(Life Sciences, IF=5.2)
發(fā)表時間:2024/6/9
作者:Jiang T, Huang J, Xu B, et al.
作者單位:中國農(nóng)業(yè)大學
使用產(chǎn)品:IHC DAB
https://pubmed.ncbi.nlm.nih.gov/38843067/
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24.?Mycobacterium tuberculosis FadD18 Promotes Proinflammatory Cytokine Secretion to Inhibit the Intracellular Survival of Bacillus Calmette–Guérin.(Cells, IF=5.1)
發(fā)表時間:2024/6/11
作者:Peng Y, Tang T, Li Q, et al.
作者單位:華中農(nóng)業(yè)大學
使用產(chǎn)品:Human TNF-α, IL-6 and IL-1β ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38920649/
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25.?Impact of Hypoxia-Inducible Factor-1α on Host Immune Metabolism and Tissue Damage During Mycobacterium bovis Infection.(The Journal of Infectious Diseases, IF=5)
發(fā)表時間:2024/6/6
作者:Nan Y, Wang Y, Dong Y, et al.
作者單位:中國農(nóng)業(yè)大學
使用產(chǎn)品:Mouse IL-1β, IL-6, IL-10, IL-17 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38843067/
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26.?Peripheral cytokine interleukin-10 alleviates perihematomal edema after intracerebral hemorrhage via interleukin-10 receptor/JAK1/STAT3 signaling.(CNS Neuroscience & Therapeutics, IF=4.8)
發(fā)表時間:2024/6/12
作者:Xu Y, Wang K, Dai Y, et al.
作者單位:陸軍軍醫(yī)大學
使用產(chǎn)品:Mouse IL-10 ELISA Kit
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38867395/
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27.?Identification of Effective Components in Flos Chrysanthemi Indici for Alleviating Gouty Inflammation through Integrated Absorption and Metabolism Studies.(Food Bioscience, IF=4.8)
發(fā)表時間:2024/6/20
作者:Huang Y, Xu T, Yuan Y, et al.
作者單位:華中農(nóng)業(yè)大學
使用產(chǎn)品:Human IL-1β, IL-18, IL-6 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S2212429224010460
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28.?Taraxasterol protects against acetaminophen-induced hepatotoxicity by reducing liver inflammatory response and ameliorating oxidative stress in mice.(International Immunopharmacology, IF=4.8)
發(fā)表時間:2024/6/28
作者:Lin W, Gu B, Gu Y, et al.
作者單位:南通大學
使用產(chǎn)品:Mouse IL-1β, TNF-α, IL-6 and MCP-1 ELISA Kits
樣本類型:肝臟組織
https://pubmed.ncbi.nlm.nih.gov/38943970/
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29.?The antiangiogenic effect of total saponins of Panax japonicus C.A. Meyer in rheumatoid arthritis is mediated by targeting the HIF-1α/VEGF/ANG-1 axis.(Journal of Ethnopharmacology, IF=4.8)
發(fā)表時間:2024/6/3
作者:Guo X, Zhang J, Feng Z, et al.
作者單位:廣州中醫(yī)藥大學
使用產(chǎn)品:Mouse HIF-1α, VEGF-A and ANG-1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38838922/
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30.?Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway.(Molecular Neurobiology, IF=4.6)
發(fā)表時間:2024/6/18
作者:Ge Y, Dou X, Chen P, et al.
作者單位:華中科技大學同濟醫(yī)學院
使用產(chǎn)品:Mouse IL-1β, IL-10 and IL-4 ELISA Kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38886327/
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31.?Role of transforming growth factor-β1 pathway in angiogenesis induced by chronic stress in colorectal cancer.(Cancer Biology & Therapy, IF=4.4)
發(fā)表時間:2024/6/10
作者:Zhang J, Deng Y T, Liu J, et al.
作者單位:重慶醫(yī)科大學附屬第一醫(yī)院
使用產(chǎn)品:Human TGF-β1 ELISA kit; Mouse TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38857055/
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32.?Antioxidant, Antimicrobial, and Anti-Inflammatory Effects of Liriodendron chinense Leaves.(ACS Omega, IF=3.7)
發(fā)表時間:2024/6/10
作者:Wang Y L, Ni Q, Zeng W H, et al.
作者單位:南方醫(yī)科大學
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits
樣本類型:肺組織
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11209703/
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33.?Enhanced anti-tumor activity mediated by combination chimeric antigen receptor T cells targeting GD2 and GPC2 in high-risk neuroblastoma.(Cytotherapy, IF=3.7)
發(fā)表時間:2024/5/31
作者:Wu H, Zhang G, Liu Z, et al.
作者單位:首都醫(yī)科大學宣武醫(yī)院
使用產(chǎn)品:Mouse IFN-γ, IL-2, TNF-α, IL-15, TGF-β1and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38904586/
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34.?DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis.(Neurochemical Research, IF=3.7)
發(fā)表時間:2024/6/4
作者:Cui Y, Hu Z, Wang L, et al.
作者單位:中南大學
使用產(chǎn)品:Rat TNF-α, IL-1β and IL-6 ELISA Kits
樣本類型:海馬組織
https://pubmed.ncbi.nlm.nih.gov/38834844/
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35.?CCL22 Induces the Polarization of Immature Dendritic Cells into Tolerogenic Dendritic Cells in Radiation-Induced Lung Injury through the CCR4–Dectin2–PLC-γ2–NFATC2–Nr4a2–PD-L1 Signaling Pathway.(The Journal of Immunology, IF=3.6)
發(fā)表時間:2024/6/10
作者:Liu B, Wang Y, Ma L, et al.
作者單位:北京放射醫(yī)學研究所
使用產(chǎn)品:Mouse CCL22, IFN-γ, IL-1β, IL-12p70, IL-6 and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/38856585/
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36.?Specific immunological characteristics and risk factor of XBB variants re-infection in nasopharyngeal carcinoma patients after BA.5 infection.(Virology, IF=2.8)
發(fā)表時間:2024/6/28
作者:Lei Y, Xu N, Niu C, et al.
作者單位:廣州醫(yī)科大學附屬第二醫(yī)院
使用產(chǎn)品:TMB (standard sensitivity)
https://www.sciencedirect.com/science/article/abs/pii/S0042682224001636
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37.?Aspirin and Celecoxib Regulate Notch1/Hes1 Pathway to Prevent Pressure Overload-Induced Myocardial Hypertrophy.(International Heart Journal, IF=1.2)
發(fā)表時間:2024/5/31
作者:Wei M, Lu Z, Zhang H, et al.
作者單位:內蒙古醫(yī)科大學
使用產(chǎn)品:Rat IL-6, IL-1β, TNF-α and IL-10 ELISA Kits
樣本類型:心臟組織
https://pubmed.ncbi.nlm.nih.gov/38825493/
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