多年來(lái),大量研究證明免疫細(xì)胞和腫瘤細(xì)胞產(chǎn)生的內(nèi)源性IFN-I在調(diào)控腫瘤生長(zhǎng)和抗腫瘤治療中有重要作用。IFN-I在血液惡性腫瘤和實(shí)體瘤中都有良好的臨床療效。目前,臨床上可以通過(guò)注射重組人IFN提高其瘤內(nèi)水平,但其腫瘤靶向性差、療效低,且易產(chǎn)生明顯的全身免疫毒性。因此,如何選擇性提高瘤內(nèi)IFN等免疫分子水平,同時(shí)克服其誘導(dǎo)的免疫耐受,是腫瘤免疫治療領(lǐng)域亟待解決的重要科學(xué)問(wèn)題。近日,中國(guó)科學(xué)院上海藥物研究所李亞平課題組在國(guó)際頂級(jí)期刊《Nature Nanotechnology》上在線發(fā)表了題為”T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy”的文章,展示了工程化T淋巴細(xì)胞膜修飾干擾素(IFN)表觀遺傳納米誘導(dǎo)劑改善腫瘤免疫治療的最新研究成果。該團(tuán)隊(duì)創(chuàng)造性地設(shè)計(jì)構(gòu)建了一種仿生納米囊泡,將藥物ORY-1001包載到PD1高表達(dá)的T細(xì)胞膜囊中,構(gòu)建了一種新型免疫調(diào)節(jié)劑(簡(jiǎn)稱OPEN)。OPEN能特異性靶向腫瘤,高效誘導(dǎo)瘤內(nèi)IFN分泌,上調(diào)腫瘤細(xì)胞PDL1和主要組織相容性復(fù)合體-I(MHC-I)等的表達(dá)。該研究開(kāi)拓了精準(zhǔn)遞送+智能釋藥一體化技術(shù)調(diào)控表觀遺傳、克服免疫耐受、改善腫瘤免疫治療的新方向,為提高包括IFN在內(nèi)的兼具抗癌活性和促進(jìn)免疫逃逸的活性分子療效以及降低其免疫副作用提供了新思路。
本文中使用了欣博盛Mouse IFN-α和IFN-β ELISA試劑盒檢測(cè)了細(xì)胞培養(yǎng)上清和腫瘤組織勻漿樣本中的IFN-α和IFN-β濃度,使用Mouse PD1 ELISA試劑盒檢測(cè)了OPEN上PD-1蛋白的濃度。
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1.文章題目:T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy.
期 ???刊:Nature Nanotechnology(影響因子:39.213)
發(fā)表時(shí)間:27 September 2021
作 ???者:Zhai Y, Wang J, Lang T, et al.
作者單位:中國(guó)科學(xué)院上海藥物研究所
使用產(chǎn)品:Mouse IFN-α, IFN-β and?PD1 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34580467/
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2.文章題目:A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.
期 ???刊:Nature Communications(影響因子:14.919)
發(fā)表時(shí)間:30 September 2021
作 ???者:Wang G, Xie L, Li B, et al.
作者單位:澳門大學(xué)
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6 and IL-12p70 ELISA Kits ?
https://pubmed.ncbi.nlm.nih.gov/34593794/
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3.文章題目:Selenoprotein K deficiency-induced apoptosis: A role for calpain and the ERS pathway.
期 ???刊:Redox Biology(影響因子:11.799)
發(fā)表時(shí)間:29 September 2021
作 ???者:Jia S Z, Xu X W, Zhang Z H, et al.
作者單位:深圳大學(xué)?
使用產(chǎn)品:anti-rabbit and anti-mouse HRP conjugated secondary antibodies
https://pubmed.ncbi.nlm.nih.gov/34601426/
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4.文章題目:Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy.
期 ???刊:Acta Pharmaceutica Sinica B(影響因子:11.413)
發(fā)表時(shí)間:25 September 2021
作 ???者:Ye J, Hou B, Chen F, et al.
作者單位:中國(guó)科學(xué)院上海藥物研究所
使用產(chǎn)品:Mouse IFN-γ ELISA Kit
樣本類型:腫瘤組織
https://www.sciencedirect.com/science/article/pii/S2211383521003634
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5.文章題目:Chemo-photothermal immunotherapy for eradication of orthotopic tumors and inhibition of metastasis by intratumoral injection of polydopamine versatile hydrogels.
期 ???刊:Acta Pharmaceutica Sinica B(影響因子:11.413)?
發(fā)表時(shí)間:7 September 2021
作 ???者:Zhuang B, Chen T, Huang Y, et al.
作者單位:中國(guó)醫(yī)學(xué)科學(xué)院放射醫(yī)學(xué)研究所
使用產(chǎn)品:Mouse TNF-α, IL-6, IFN-γ ELISA Kits
https://www.sciencedirect.com/science/article/pii/S2211383521003415
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6.文章題目:Natural killer cell-derived extracellular vesicle significantly enhanced adoptive T cell therapy against solid tumors via versatilely immunomodulatory coordination.
期 ???刊:Science China Chemistry(影響因子:9.445)
發(fā)表時(shí)間:17 September 2021
作 ???者:Nie W, Fan W, Jiang A, et al.
作者單位:北京理工大學(xué)
使用產(chǎn)品:Mouse IFN-γ, IL-6 and TNF-α ELISA Kits
https://link.springer.com/article/10.1007/s11426-021-1085-8
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7.文章題目:Carbon ion (12C6+) irradiation induces the expression of Klrk1 in lung cancer and optimizes the tumor microenvironment based on the NKG2D/NKG2D-Ls pathway.
期 ???刊:Cancer Letters(影響因子:8.679)
發(fā)表時(shí)間:4 September 2021
作 ???者:Wang J, Dai Z, Miao Y, et al.
作者單位:蘭州大學(xué)第一醫(yī)院
使用產(chǎn)品:Mouse IL-10 and TGF-β1 ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/34492331/
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8.文章題目:Inhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway.
期 ???刊:Cell Death & Disease(影響因子:8.469)
發(fā)表時(shí)間:28 September 2021
作 ???者:Liang T, Chen T, Qiu J, et al.
作者單位:中山大學(xué)孫逸仙紀(jì)念醫(yī)院
使用產(chǎn)品:Human IL-6 ELISA Kit ????
https://pubmed.ncbi.nlm.nih.gov/34584074/
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9.文章題目:Results of a 30-day safety assessment in young mice orally exposed to polystyrene nanoparticles.
期 ???刊:Environmental Pollution(影響因子:8.071)
發(fā)表時(shí)間:14 September 2021
作 ???者:Xiao J, Jiang X, Zhou Y, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0269749121017668
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10.文章題目:Machine learning enables discovery of Gentianine targeting TLR4/NF-κB pathway to repair ischemic stroke injury.
期 ???刊:Pharmacological Research(影響因子:7.658)
發(fā)表時(shí)間:24 September 2021
作 ???者:Wang N, Liu Y, Jia C, et al.
作者單位:北京中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β?and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34563661/
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11.文章題目:Sophora subprostrate polysaccharide regulates histone acetylation to inhibit inflammation in PCV2-infected murine splenic lymphocytes in vitro and in vivo.
期 ???刊:International Journal of Biological Macromolecules(影響因子:6.953)
發(fā)表時(shí)間:22 September 2021
作 ???者:Cao M X, Yang J, Wang X R, et al.
作者單位:廣西大學(xué)
使用產(chǎn)品:Mouse?TNF-α, IL-6 and IL-10 ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0141813021020493
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12.文章題目:Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model.
期 ???刊:Cancer Gene Therapy(影響因子:5.987)
發(fā)表時(shí)間:24 September 2021
作 ???者:Zhang H, Xie W, Zhang Y, et al.
作者單位:廣西醫(yī)科大學(xué)附屬腫瘤醫(yī)院
使用產(chǎn)品:Mouse GM-CSF ELISA Kit ??
https://pubmed.ncbi.nlm.nih.gov/34561555/
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13.文章題目:Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect.
期 ???刊:Phytotherapy Research(影響因子:5.878)
發(fā)表時(shí)間:01 September 2021
作 ???者:Yu S, Chen Y, Xiang Y, et al.
作者單位:上海中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/34472141/
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14.文章題目:Sacubitril/valsartan alleviates experimental autoimmune myocarditis by inhibiting Th17 cell differentiation independently of the NLRP3 inflammasome pathway.
期 ???刊:Frontiers in Pharmacology(影響因子:5.81)
發(fā)表時(shí)間:15 September 2021
作 ???者:Liang W, Xie B K, Ding P W, et al.
作者單位:華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院?
使用產(chǎn)品:Mouse IFN-γ and IL-17 ELISA Kits ?
https://pubmed.ncbi.nlm.nih.gov/34603042/
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15.文章題目:The Chinese Herbal Prescription JieZe-1 Inhibits Membrane Fusion and the Toll-like Receptor Signaling Pathway in a Genital Herpes Mouse Model.
期 ???刊:Frontiers in pharmacology(影響因子:5.81)
發(fā)表時(shí)間:24 September 2021
作 ???者:Duan Q, Liu T, Huang C, et al.
作者單位:華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院
使用產(chǎn)品:Mouse IL-6, IFN-β and TNF-α ELISA Kits
樣本類型:陰道組織
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497740/
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16.文章題目:Xueshuantong Improves Functions of Lymphatic Ducts and Modulates Inflammatory Responses in Alzheimer’s Disease Mice.
期 ???刊:Frontiers in Pharmacology(影響因子:5.81)
發(fā)表時(shí)間:28?September 2021
作 ???者:Zheng R, Huang Y, Zhou Q
作者單位:北京大學(xué)深圳研究生院
使用產(chǎn)品:anti-rabbit and anti-mouse HRP conjugated secondary antibodies
https://www.frontiersin.org/articles/10.3389/fphar.2021.605814/full
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17.文章題目:Exposure to carbon black nanoparticles during pregnancy aggravates lipopolysaccharide-induced lung injury in offspring: an intergenerational effect.
期 ???刊:American Journal of Physiology-Lung Cellular and Molecular Physiology(影響因子:5.464)
發(fā)表時(shí)間:29 September 2021
作 ???者:Tang Q, Tu B, Jiang X, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/34585979/
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18.文章題目:Probing the conjugation of epigallocatechin gallate with β-lactoglobulin and its in vivo desensitization efficiency.
期 ???刊:Food & Function(影響因子:5.396)
發(fā)表時(shí)間:25 September 2021
作 ???者:Zhang X, Li S, Shao X, et al.
作者單位:齊魯理工學(xué)院?
使用產(chǎn)品:Mouse?IgE, IL-4, IL-5,?IL-10 and IL-13 ELISA Kits
https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo02293h/unauth
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19.文章題目:Effective-components combination improves airway remodeling in COPD rats by suppressing M2 macrophage polarization via the inhibition of mTORC2 activity.
期 ???刊:Phytomedicine(影響因子:5.34)?
發(fā)表時(shí)間:13 September 2021
作 ???者:Liu L, Qin Y, Cai Z, et al.
作者單位:河南中醫(yī)藥大學(xué)
使用產(chǎn)品:Rat IL-6, IL-1β and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34600177/
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20.文章題目:Chicken bone marrow mesenchymal stem cells improve lung and distal organ injury.
期 ???刊:Scientific Reports(影響因子:4.379)
發(fā)表時(shí)間:10 September 2021
作 ???者:Niu H, Song H, Guan Y, et al.
作者單位:哈爾濱體育學(xué)院
使用產(chǎn)品:Mouse CXCL1, IL-1β and TNF-α ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/34508136/
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21.文章題目:Guaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages.
期 ???刊:Phytochemistry(影響因子:4.072)
發(fā)表時(shí)間:21 September 2021
作 ???者:Wang Q, Zhang T, Ke C Q, et al.
作者單位:中國(guó)科學(xué)院上海藥物研究所
使用產(chǎn)品:Human IL-1β ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34555775/
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22.文章題目:Omp31 of Brucella Inhibits NF-κB p65 Signaling Pathway by Inducing Autophagy in BV-2 Microglia.
期 ???刊:Neurochemical Research(影響因子:3.996)
發(fā)表時(shí)間:18 September 2021
作 ???者:Wang Z, Wang G, Wang Y, et al.
作者單位:寧夏醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34536195/
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23.文章題目:Effect of silicon-doped calcium phosphate cement on angiogenesis based on controlled macrophage polarization.
期 ???刊:Acta Biochimica et Biophysica Sinica(影響因子:3.848)
發(fā)表時(shí)間:18 September 2021
作 ???者:Lee S, Li Z, Meng D, et al.
作者單位:復(fù)旦大學(xué)附屬中山醫(yī)院
使用產(chǎn)品:Mouse IL-10 ELISA Kit ??
https://pubmed.ncbi.nlm.nih.gov/34536273/
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24.文章題目:The mitochondria-targeting antioxidant MitoQ alleviated Lipopolysaccharide/D-galactosamine-induced acute liver injury in mice.
期 ???刊:Immunology Letters(影響因子:3.685)
發(fā)表時(shí)間:12 September 2021
作 ???者:Hu K, Xiao L, Li L, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34525396/
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25.文章題目:The protective benefit of heme oxygenase-1 gene modified human placenta-derived Mesenchymal stem cell in N-nitro-L-arginine methyl ester-induced preeclampsia-like rat model: Possible implications for placental angiogenesis.
期 ???刊:Stem Cells and Development(影響因子:3.272)
發(fā)表時(shí)間:02 September 2021
作 ???者:Liu Y, Shi H R, Xu G, et al.
作者單位:武漢協(xié)和醫(yī)院
使用產(chǎn)品:Rat VEGF?ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34470469/
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26.文章題目:Activation of vagovagal reflex prevents hepatic ischemia/reperfusion-induced lung injury via anti-inflammatory and antioxidant effects.
期 ???刊:Experimental Physiology(影響因子:2.969)
發(fā)表時(shí)間:17 September 2021
作 ???者:Deng J, Jiang Y, Wang M, et al.
作者單位:武漢大學(xué)人民醫(yī)院
使用產(chǎn)品:Rat IL-1β, IL-6, IL-10, IL-17 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34533881/
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27.文章題目:Efficacy of Enhanced Cytokine-Induced Killer Cells as an Adjuvant Immunotherapy for Renal Cell Carcinoma: Preclinical and Clinical Studies.
期 ???刊:Journal of Healthcare Engineering(影響因子:2.682)?
發(fā)表時(shí)間:08 September 2021
作 ???者:Yang Y, Wang R Q, Zhong Y M, et al.
作者單位:昆明醫(yī)科大學(xué)附屬延安醫(yī)院
使用產(chǎn)品:Human TNF-α, IFN-γ, perforin and granzyme B ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/34540187/
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28.文章題目:CMPK2 accelerates liver ischemia/reperfusion injury via the NLRP3 signaling pathway.
期 ???刊:Experimental and Therapeutic Medicine(影響因子:2.447)
發(fā)表時(shí)間:24 September 2021
作 ???者:Luo Y, Zheng D, Mou T, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Mouse IL?18 and IL?1β ELISA Kits ???
https://www.spandidos-publications.com/10.3892/etm.2021.10793
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29.文章題目:Fatty acid-binding protein 5 activates cyclooxygenase-2 and promotes hypoxic injury in LO2?cells.
期 ???刊:Molecular & Cellular Toxicology(影響因子:1.08)
發(fā)表時(shí)間:17 September 2021
作 ???者:Pan L, Pang Y, Xiao H, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Human IL-6 and TNF-α ELISA Kits ???
https://link.springer.com/article/10.1007/s13273-021-00158-1
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