肥胖癥是一種慢性代謝性疾病,肥胖可導(dǎo)致一系列嚴(yán)重的并發(fā)癥,比如冠心病、糖尿病、高血壓、脂肪肝、癌癥等,目前肥胖癥的主要治療方法包括生活方式干預(yù)、藥物治療和手術(shù)治療,治療機制多種多樣,但是每種方法有自己的缺點,并且由于多種因素,減肥效果有限。因此,迫切需要尋找安全有效創(chuàng)新的方法來對抗肥胖。光動力療法和脂肪棕化誘導(dǎo)是兩種獨特的減肥方法,前者起效迅速但范圍小,后者作用相對緩慢但影響廣泛。如果將這兩種策略結(jié)合起來治療肥胖癥將有重要意義。2021年2月,廈門大學(xué)聶立銘教授團隊在國際知名期刊Nature Nanotechnology(影響因子:31.538)上在線發(fā)表了題目為“Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes”的文章,提出了一種新穎的光聲分子成像護航下的光動力/棕化抗肥胖策略,為肥胖治療及療效評估提供了一個新思路。
本研究通過基因工程技術(shù)改造了乙肝病毒核心蛋白顆粒,將可追蹤的光敏劑酞菁鋅四磺酸鋅ZnPcS4和褐變劑羅格列酮(rosiglitazone)結(jié)合到乙型肝炎脂肪靶向蛋白復(fù)合結(jié)構(gòu)中,于肥胖小鼠中靜脈注射后,該復(fù)合物特異性結(jié)合白色脂肪組織,尤其是那些血液供應(yīng)豐富的組織,并由于ZnPcS4光動力學(xué)和羅格列酮褐變的協(xié)同作用而促使脂肪減少。使用光聲分子成像,能夠可視化監(jiān)測脂肪可能發(fā)生的效應(yīng)變化。
本研究中使用了欣博盛TNF-α, IL-1β and IL-6 ELISA試劑盒檢測了小鼠白色脂肪組織勻漿中細(xì)胞因子的濃度。
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1.文章題目:Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes.
期 ???刊:Nature Nanotechnology(影響因子:31.538)
發(fā)表時間:1 February 2021
作 ???者:Chen R, Huang S, Lin T, et al.
作者單位:廈門大學(xué)?
使用產(chǎn)品:Mouse TNF-α, IL-1β and IL-6 ELISA Kits
樣本類型:白色脂肪組織
https://pubmed.ncbi.nlm.nih.gov/33526836/
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2.文章題目:Bacteria-Anchoring Hybrid Liposome Capable of Absorbing Multiple Toxins for Antivirulence Therapy of Escherichia coli Infection.
期 ???刊:ACS nano(影響因子:14.588)
發(fā)表時間:19 February 2021
作 ???者:Jiang L, Zhu Y, Luan P, et al.
作者單位:上海中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β and IL-6 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33606516/
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3.文章題目:Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages.
期 ???刊:Science Advances(影響因子:13.116)
發(fā)表時間:10 February 2021
作 ???者:Yu Y, Dai K, Gao Z, et al.
作者單位:華東理工大學(xué)
使用產(chǎn)品:Mouse VEGF, TNF-α, IL-1β, IL-6, IL-4, IL-10 and TGF-β1 ELISA Kits ?
https://pubmed.ncbi.nlm.nih.gov/33568481/
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4.文章題目:Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment.
期 ???刊:Nature communications(影響因子:12.121)
發(fā)表時間:3 February 2021
作 ???者:Bai H, Wang J, Phan C U, et al.
作者單位:浙江大學(xué)
使用產(chǎn)品:Mouse IL-6, TNF-α, VEGF and MMP-9 ELISA Kits ????
https://pubmed.ncbi.nlm.nih.gov/33536421/
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5.文章題目:A Multi-Targeted Nanoconjugate for Light-Driven Therapy of Chronic Wounds.
期 ???刊:Chemical Engineering Journal(影響因子:10.652)
發(fā)表時間:6 February 2021
作 ???者:Niu Y, Zhang J, Sun J, et al.
作者單位:天津醫(yī)科大學(xué)朱憲彝紀(jì)念醫(yī)院
使用產(chǎn)品:Rat IL-1β, IL-6 and TNF-α ELISA Kits
樣本類型:皮膚組織
https://www.sciencedirect.com/science/article/abs/pii/S1385894721004290
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6.文章題目:MEK inhibition remodels the immune landscape of mutant KRAS tumors to overcome resistance to PARP and immune checkpoint inhibitors.
期 ???刊:Cancer Research(影響因子:9.727)
發(fā)表時間:10 February 2021
作 ???者:Yang B, Li X, Fu Y, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院附屬同濟醫(yī)院
使用產(chǎn)品:Human?IL-6 (high sensitivity), GM-CSF?and?IP-10/CXCL10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33589518/
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7.文章題目:Development of a novel RNAi therapy: Engineered miR-31 exosomes promoted the healing of diabetic wounds.
期 ???刊:Bioactive Materials(影響因子:8.724)
發(fā)表時間:20 February 2021
作 ???者:Huang J, Yu M, Yin W, et al.
作者單位:上海市第六人民醫(yī)院
使用產(chǎn)品:Human VEGF and bFGF ELISA Kits ?
https://www.sciencedirect.com/science/article/pii/S2452199X21000608
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8.文章題目:Three-dimensional decellularized tumor extracellular matrices with different stiffness as bioengineered tumor scaffolds.
期 ???刊:Bioactive Materials(影響因子:8.724)
發(fā)表時間:15 February 2021
作 ???者:Lv Y, Wang H, Li G, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://www.sciencedirect.com/science/article/pii/S2452199X21000566
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9.文章題目:Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a.
期 ???刊:Aging and disease(影響因子:5.402)
發(fā)表時間:1 February 2021
作 ???者:Xu M, Su X, Xiao X, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所?
使用產(chǎn)品:HRP-conjugated anti-rabbit-IgG and HRP-conjugated anti-mouse-IgG
https://pubmed.ncbi.nlm.nih.gov/33532131/
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10.文章題目:Structure characterization and in vitro immunomodulatory activities of carboxymethyl pachymaran.
期 ???刊:International Journal of Biological Macromolecules(影響因子:5.162)
發(fā)表時間:10 February 2021
作 ???者:Liu F, Liu Y, Feng X, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits ?
https://www.sciencedirect.com/science/article/abs/pii/S0141813021003275
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11.文章題目:Silencing Smad7 potentiates BMP2-induced chondrogenic differentiation and inhibits endochondral ossification in human synovial-derived mesenchymal stromal cells.
期 ???刊:Stem Cell Research & Therapy(影響因子:5.116)
發(fā)表時間:15 February 2021
作 ???者:Xiao P, Zhu Z, Du C, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Human BMP-2 ELISA Kit???
https://pubmed.ncbi.nlm.nih.gov/33588941/
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12.文章題目:The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53.
期 ???刊:Acta Pharmacologica Sinica(影響因子:5.064)
發(fā)表時間:1 February 2021
作 ???者:Li W, Herkilini A, Tang Y, et al.
作者單位:重慶大學(xué)?
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/33526870/
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13.文章題目:Upregulation of IL-15 in the placenta alters trophoblasts behavior contributing to gestational diabetes mellitus.
期 ???刊:Cell & Bioscience(影響因子:5.026)
發(fā)表時間:8 February 2021
作 ???者:Li J, Li Y, Zhou X, et al.
作者單位:華中科技大學(xué)
使用產(chǎn)品:IHC Kit
https://pubmed.ncbi.nlm.nih.gov/33557944/
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14.文章題目:Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5.
期 ???刊:Biomedicine & Pharmacotherapy(影響因子:4.545)
發(fā)表時間:9 February 2021
作 ???者:Hua Y, Jia Y, Zhang X, et al.
作者單位:甘肅農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-10 and TGF-β1 ELISA Kits ???
https://www.sciencedirect.com/science/article/pii/S0753332221001050
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15.文章題目:Recombinant ArgF PLGA nanoparticles enhances BCG induced immune responses against Mycobacterium bovis infection.
期 ???刊:Biomedicine & Pharmacotherapy(影響因子:4.545)
發(fā)表時間:6 February 2021
作 ???者:Ni J, Liu Y, Hussain T, et al.
作者單位:中國農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IFN-γ, IgG, IgA, TNF-α, IL-1β and IL-10 ELISA Kits
樣本類型:支氣管肺泡灌洗液(IgA)
https://pubmed.ncbi.nlm.nih.gov/33561646/
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16.文章題目:Ripened Pu-erh Tea Extract Promotes Gut Microbiota Resilience against Dextran Sulfate Sodium Induced Colitis.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:4.192)?
發(fā)表時間:11 February 2021
作 ???者:Huang Y, Yang Q, Mi X, et al.
作者單位:南昌大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33570405/
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17.文章題目:Ameliorative effects of total coumarins from the fructus of Cnidium monnieri (L.) Cuss. on 2, 4-dinitrochlorobenzene-induced atopic dermatitis in rats.
期 ???刊:Phytotherapy Research(影響因子:4.087)
發(fā)表時間:26 February 2021
作 ???者:Yu Z, Deng T, Wang P, et al.
作者單位:重慶大學(xué)附屬中心醫(yī)院
使用產(chǎn)品:Rat TNF-α, IFN-γ and IL-4 ELISA Kits
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.7052
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18.文章題目:Interferon-γ activated T-cell IRGM–autophagy axis in oral lichen planus.
期 ???刊:International Immunopharmacology(影響因子:3.943)
發(fā)表時間:24 February 2021
作 ???者:Tan Y Q, Wang F, Ma R J, et al.
作者單位:武漢大學(xué)
使用產(chǎn)品:Human IFN-γ ELISA Kit
https://www.sciencedirect.com/science/article/pii/S1567576921001144
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19.文章題目:GITRL on dendritic cells aggravates house dust mite-induced airway inflammation and airway hyperresponsiveness by modulating CD4+ T cell differentiation.
期 ???刊:Respiratory Research(影響因子:3.924)
發(fā)表時間:8 February 2021
作 ???者:Wang Y, Liao K, Liu B, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse IgE ELISA Kit ??
https://pubmed.ncbi.nlm.nih.gov/33557842/
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20.文章題目:GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway.
期 ???刊:Life Sciences(影響因子:3.647)?
發(fā)表時間:10 February 2021
作 ???者:Li J, Ma J, Li M, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院
使用產(chǎn)品:Mouse TNF-α, IL-6, IL-10 and IL-1β ELISA Kits
https://www.sciencedirect.com/science/article/abs/pii/S0024320521001776
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21.文章題目:Annexin A1 attenuates neutrophil migration and IL-6 expression through Fpr2 in a mouse model of Streptococcus suis-induced meningitis.
期 ???刊:Infection and Immunity(影響因子:3.201)
發(fā)表時間:16 February 2021
作 ???者:Ni C, Gao S, Zheng Y, et al.
作者單位:軍事醫(yī)學(xué)科學(xué)院?
使用產(chǎn)品:Mouse CXCL1/KC, CXCL2/MIP-2, IL-6 and IL-1β ELISA Kits
樣本類型:大腦組織
https://pubmed.ncbi.nlm.nih.gov/33318141/
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22.文章題目:PCSK9 mediates the oxidative low?density lipoprotein?induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
期 ???刊:International Journal of Molecular Medicine(影響因子:3.098)
發(fā)表時間:11 February 2021
作 ???者:Zeng J, Tao J, Xi L, et al.
作者單位:南華大學(xué)?
使用產(chǎn)品:Human IL-1β ELISA Kit ?
https://pubmed.ncbi.nlm.nih.gov/33576442/
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23.文章題目:GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis.
期 ???刊:Biochemical and Biophysical Research Communications(影響因子:2.985)
發(fā)表時間:22 February 2021
作 ???者:Guo J, Zheng J, Mu M, et al.
作者單位:西安交通大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Human IL-1β ELISA Kit
https://www.sciencedirect.com/science/article/pii/S0006291X21002278
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24.文章題目:Dexmedetomidine attenuates lipopolysaccharide induced acute liver injury in rats by inhibiting caveolin-1 downstream signaling pathway.
期 ???刊:Bioscience Reports(影響因子:2.942)
發(fā)表時間:8 February 2021
作 ???者:Tong F, Shen W, Song P, et al.
作者單位:湖州市中心醫(yī)院
使用產(chǎn)品:Rat?IL-1β and IL-18 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33558888/
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25.文章題目:Acetate Downregulates the Activation of NLRP3 Inflammasomes and Attenuates Lung Injury in Neonatal Mice With Bronchopulmonary Dysplasia.
期 ???刊:Frontiers in Pediatrics(影響因子:2.634)
發(fā)表時間:4 February 2021
作 ???者:Zhang Q, Ran X, He Y, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse IL-18 ELISA Kit ??
樣本類型:肺組織
https://pubmed.ncbi.nlm.nih.gov/33614540/
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26.文章題目:Stattic alleviates acute hepatic damage induced by LPS/d-galactosamine in mice.
期 ???刊:Innate Immunity(影響因子:2.298)
發(fā)表時間:12 February 2021
作 ???者:Li S, Hu K, Li L, et al.
作者單位:重慶醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/33576722/
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27.文章題目:Phytochemical profile and anti-inflammatory activity of the fraction from Artemisia lavandulaefolia.
期 ???刊:Chemistry & Biodiversity(影響因子:2.039)
發(fā)表時間:2 February 2021
作 ???者:Zhang L B, Guo L M, Wang F L, et al.
作者單位:新鄉(xiāng)醫(yī)學(xué)院
使用產(chǎn)品:Mouse IL-1β and TNF-α ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/33528898/
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28.文章題目:Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway.
期 ???刊:Chinese Journal of Natural Medicines(影響因子:2.014)
發(fā)表時間:25 February 2021
作 ???者:Li-Yan L E I, Rui-Cheng W, Ya-Lei P A N, et al.
作者單位:陜西中醫(yī)藥大學(xué)?
使用產(chǎn)品:Mouse IL-1β, TNF-α, IL-10 and IL-6 ELISA Kits ?
https://www.sciencedirect.com/science/article/pii/S1875536421600122
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29.文章題目:Intracellular ethanol-mediated oxidation and apoptosis in HepG2/CYP2E1 cells impaired by two active peptides from seahorse (Hippocampus kuda bleeler) protein hydrolysates via the Nrf2/HO-1 and akt pathways.
期 ???刊:Food Science & Nutrition(影響因子:1.797)
發(fā)表時間:February 2021
作 ???者:Qian Z J, Chen M F, Chen J, et al.
作者單位:廣東海洋大學(xué)深圳研究院
使用產(chǎn)品:Human TNF-α ELISA Kit ??
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.2133
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30.文章題目:ETS1 polymorphism rs73013527 in relation to serum RANKL levels among patients with RA.
期 ???刊:Medicine(影響因子:1.552)?
發(fā)表時間:5 February 2021
作 ???者:Yang B, Luo L, Chen L, et al.
作者單位:四川大學(xué)華西醫(yī)院?
使用產(chǎn)品:Human RANKL ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/33592912/
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