?近期,溫州醫(yī)科大學(xué)的沈建良課題組、蔡曉軍課題組與鄧輝課題組合作在《Advanced Science》(IF=15.1)上發(fā)表題為“Cascade Reactions Catalyzed by Gold Hybrid Nanoparticles Generate CO Gas Against Periodontitis in Diabetes.”(金混合納米粒子催化級聯(lián)反應(yīng)產(chǎn)生一氧化碳氣體對抗糖尿病牙周炎)的研究,為未來治療糖尿病牙周炎提供了有益的啟示。
由于糖尿病牙周炎存在局部炎癥,其特點是葡萄糖濃度過高、細菌感染和高氧化應(yīng)激,因此治療糖尿病牙周炎是一項重大挑戰(zhàn)。在該項研究中,研究團隊將介孔二氧化硅納米顆粒(MSN)綴合了金納米顆粒(Au NPs)并負載了羰基錳,從而制備出一種一氧化碳(CO)增強型多酶協(xié)同雜化納米平臺(MSN-Au@CO)。Au NPs的類葡萄糖氧化酶活性可催化葡萄糖氧化成過氧化氫(H2O2)和葡萄糖酸,然后通過類過氧化物酶活性將 H2O2 轉(zhuǎn)化為羥自由基(-OH),從而消滅細菌。此外,H2O2產(chǎn)生的CO與Au NPs對受到脂多糖攻擊的巨噬細胞具有協(xié)同抗炎作用。其根本機制可能是誘導(dǎo)核因子紅細胞2相關(guān)因子2(nuclear factor erythroid 2-related factor 2)減少活性氧,并抑制核因子kappa-B信號以減輕炎癥反應(yīng)。重要的是,MSN-Au@CO的抗菌和抗炎作用在患有結(jié)扎誘發(fā)的牙周炎的糖尿病大鼠模型中(ligature-induced periodontitis)得到了驗證,證實了牙周骨質(zhì)流失減少且具有良好的生物相容性。總之,MSN-Au@CO利用葡萄糖激活級聯(lián)反應(yīng)消滅細菌,并與氣體療法(gas therapy)協(xié)同調(diào)節(jié)免疫微環(huán)境,為糖尿病牙周炎的治療提供了一個潛在的方向。
(圖1:MSN-Au@CO 的構(gòu)造示意圖。)
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該項研究中,使用了欣博盛生物(NeoBioscience Technology Co, Ltd)的Mouse TNF-α, IL-6 and IL-1β?ELISA kits,用于檢測相關(guān)指標(biāo)含量。
貨號 | 產(chǎn)品名稱 | 靈敏度 | 檢測范圍 |
EMC102a | QuantiCyto??Mouse TNF-α ELISA kit(小鼠腫瘤壞死因子-α) | 15.6pg/ml | 31.25-2000pg/ml |
EMC004 |
QuantiCyto??Mouse IL-6 ELISA kit(小鼠白細胞介素-6) | 7.8pg/ml | 15.6-1000pg/ml |
EMC001b |
QuantiCyto??Mouse IL-1β ELISA kit(小鼠白細胞介素-1β) | 7.8pg/ml | 15.6-1000pg/ml |
欣博盛生物非常榮幸能夠作為供應(yīng)商為該項研究提供高品質(zhì)ELISA試劑盒,為生物醫(yī)學(xué)領(lǐng)域的科研探索貢獻一份力量。
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1.?Cascade Reactions Catalyzed by Gold Hybrid Nanoparticles Generate CO Gas Against Periodontitis in Diabetes.(Advanced Science, IF=15.1)
發(fā)表時間:2024/4/22
作者:Wang Y, Chu T, Jin T, et al.
作者單位:溫州醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38647388/
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2.?YY2/BUB3 Axis promotes SAC Hyperactivation and Inhibits Colorectal Cancer Progression via Regulating Chromosomal Instability.(Advanced Science, IF=15.1)
發(fā)表時間:2024/4/29
作者:Hosea R, Duan W, Meliala I T S, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/38682484/
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3.?Photoactive cationic conjugated microporous polymers containing pyrimidine with an 'adsorption-kill'?antibacterial strategy for infected wound healing.(Chemical Engineering Journal, IF=15.1)
發(fā)表時間:2024/4/23
作者:Liu G, Bao S, Shi J, et al.
作者單位:西南大學(xué)
使用產(chǎn)品:Goat anti-Rabbit IgG (H + L)
https://www.sciencedirect.com/science/article/abs/pii/S1385894724030808
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4.?Biofunctional lipid nanoparticles for precision treatment and prophylaxis of bacterial infections.(Science Advances, IF=13.6)
發(fā)表時間:2024/4/5
作者:Peng X, Chen J, Gan Y, et al.
作者單位:中山大學(xué)
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38578994/
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5.?Modulating macrophage phenotype for accelerated wound healing with chlorogenic acid-loaded nanocomposite hydrogel.(Journal of Controlled Release, IF=10.8)
發(fā)表時間:2024/4/5
作者:Wang S, Liu Y, Wang X, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院藥物研究所
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6 and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38575075/
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6.?Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma.(British journal of cancer, IF=8.8)
發(fā)表時間:2024/4/11
作者:Wu H, Li X, Zhang B, et al.
作者單位:首都醫(yī)科大學(xué)宣武醫(yī)院
使用產(chǎn)品:Human IL-2, IFN-γ, IL-6, IL-15 and TNF-α?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38605247/
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7.?Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.(Journal of Pharmaceutical Analysis, IF=8.8)
發(fā)表時間:2024/4/22
作者:Zhu J, Lin Y, Li G, et al.
作者單位:湖南中醫(yī)藥大學(xué)第一醫(yī)院
使用產(chǎn)品:Mouse IL-6 and IL-10 ELISA kits
?https://www.sciencedirect.com/science/article/pii/S2095177924000789
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8.?Tyrosine nitration enhances the allergenic potential of house dust mite allergen Der p 2.(Environmental Research, IF=8.3)
發(fā)表時間:2024/4/3
作者:Li Z, Tian J, Yang F.
作者單位:浙江大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-8, CCL2 and MIP-3-α ELISA kits
https://www.semanticscholar.org/paper/Tyrosine-nitration-enhances-the-allergenic-of-house-Li-Tian/456a790c843490f2ec8ddcbb176f1bf75a068d67
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9.?Hyaluronic acid modified nanocarriers for aerosolized delivery of verteporfin in the treatment of acute lung injury.(International Journal of Biological Macromolecules, IF=8.2)
發(fā)表時間:2024/4/4
作者:Cen H, Sun M, Zheng B, et al.
作者單位:廣州醫(yī)科大學(xué)附屬第五醫(yī)院
使用產(chǎn)品:Mouse IL-10, TNF-α and IL-6 ELISA kits
樣本類型:支氣管灌洗液
https://pubmed.ncbi.nlm.nih.gov/38582458/
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10.?Cyperus peptide SFRWQ inhibits oxidation and inflammation in RAW264.7 cell model.(International Journal of Biological Macromolecules, IF=8.2)
發(fā)表時間:2024/4/11
作者:Ma C, Wu X.
作者單位:內(nèi)蒙古大學(xué)
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38565370/
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11.?Characterization of a novel T cell-engaging bispecific antibody for elimination of L1CAM-positive tumors.(Biomedicine & Pharmacotherapy, IF=7.5)
發(fā)表時間:2024/4/11
作者:Yuan Y, Li J, Chen J, et al.
作者單位:上海交通大學(xué)
使用產(chǎn)品:Human Granzyme B ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38603888/
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12.?Sacubitril/Valsartan inhibits M1 type macrophages polarization in acute myocarditis by targeting C-type natriuretic peptide.(Biomedicine & Pharmacotherapy, IF=7.5)
發(fā)表時間:2024/4/5
作者:Liu C, Long Q, Yang H, et al.
作者單位:華中科技大學(xué)同濟醫(yī)學(xué)院附屬協(xié)和醫(yī)院
使用產(chǎn)品:Human IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38581923/
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13.?Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB.(Journal of Medicinal Chemistry, IF=7.3)
發(fā)表時間:2024/4/19
作者:Xie C L, Xiao H X, Song P F, et al.
作者單位:海南醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-4 and INF-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38640354/
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14.?Mouse serum albumin induces neuronal apoptosis and tauopathies.(Acta Neuropathologica Communications, IF=7.1)
發(fā)表時間:2024/4/23
作者:Hou S, Huang Y, Zhu J, et al.
作者單位:中國科學(xué)院過程工程研究所
使用產(chǎn)品:Mouse IL-1β, TNF-α and IL-6 ELISA kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38654316/
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15.?Self-Assembly of Sulfate-Containing Peptides Sequesters VEGF for Inhibiting Cancer Cell Invasion.(Biomacromolecules, IF=6.2)
發(fā)表時間:2024/4/7
作者:Song J, Shao L, Yu H, et al.
作者單位:西安交通大學(xué)
使用產(chǎn)品:Human VEGF and bFGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38584438/
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16.?Suppressive Role of Pigment Epithelium-derived Factor in a Rat Model of Corneal Allograft Rejection.(Transplantation, IF=6.2)
發(fā)表時間:2024/4/22
作者:Chu X, Yin Y, Chen S, et al.
作者單位:天津醫(yī)科大學(xué)
使用產(chǎn)品:Rat IL-17A, IL-10, and TGF-β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38644534/
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17.?Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury.(Neural Regeneration Research, IF=6.1)
發(fā)表時間:2024/4/5
作者:Chen J, Zeng X, Wang L, et al.
作者單位:中山大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-1α and TNF-α ELISA kits
https://journals.lww.com/nrronline/abstract/9900/mutual_regulation_of_microglia_and_astrocytes.256.aspx
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18.?Multicomponent Pathogen-Mimicking Nanoparticles Induce Intestinal Immune Responses against Paratuberculosis.(ACS Biomaterials Science & Engineering , IF=5.8)
發(fā)表時間:2024/4/24
作者:Liu Y, Long M, Wang Y, et al.
作者單位:中國農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-17 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38656158/
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19.?Small extracellular vesicles derived from human mesenchymal stem cells prevent Th17-dominant neutrophilic airway inflammation via immunoregulation on Th17 cells.(International Immunopharmacology, IF=5.6)
發(fā)表時間:2024/4/25
作者:He B X, Fang S B, Xie Y C, et al.
作者單位:中山大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-17A ELISA kit
樣本類型:支氣管灌洗液
https://pubmed.ncbi.nlm.nih.gov/38669946/
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20.?Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3.(Journal of Molecular Cell Biology, IF=5.5)
發(fā)表時間:2024/4/5
作者:Wang M, Li X W, Yuan S C, et al.
作者單位:國家生物醫(yī)學(xué)分析中心
使用產(chǎn)品:Mouse IFN-β ELISA kit and Human IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38578631/
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21.?Piper longum L. ameliorates gout through the MAPK/PI3K-AKT pathway.(Journal of Ethnopharmacology, IF=5.4)
發(fā)表時間:2024/4/24
作者:Wu C, Zhang Z, Bai L, et al.
作者單位:中南民族大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/38670409/
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22.?Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy.(Journal of Cellular and Molecular Medicine, IF=5.3)
發(fā)表時間:2024/4/29
作者:Huang Y, Jiang C, Liu X, et al.
作者單位:安徽醫(yī)科大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Human IL-1β, IL-18 and TNF-α ?(high sensitivity) ?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38683122/
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23.?A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice.(Journal of Cellular and Molecular Medicine, IF=5.3)
發(fā)表時間:2024/4/10
作者:Yang Z, Li C, Wang Y, et al.
作者單位:桂林醫(yī)科大學(xué)附屬醫(yī)院
使用產(chǎn)品:Mouse IL-6, IL-1β and TNF-α ELISA kits
樣本類型:肝組織
https://pubmed.ncbi.nlm.nih.gov/38597412/
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24.?A lychee fermentate with enriched acetate but lowered GABA attenuates DSS-induced colitis by reinforcing gut barrier function and modulating intestinal microbiota.(Food Bioscience, IF=5.2)
發(fā)表時間:2024/4/15
作者:Huang R, Yao H, Ji S, et al.
作者單位:暨南大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-1β and TNF-α ELISA kits
樣本類型:腸組織
https://www.sciencedirect.com/science/article/pii/S2212429224005194
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25.?Oleuropein alleviates myocardial ischemia–reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway.(Chinese Medicine, IF=4.9)
發(fā)表時間:2024/4/8
作者:He J, Huang L, Sun K, et al.
作者單位:江西中醫(yī)藥大學(xué)
使用產(chǎn)品:Rat IL-6 and TNF-αELISA kits
https://pubmed.ncbi.nlm.nih.gov/38589925/
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26.?Chimeric Porcine Parvovirus VP2 Virus-like Particles with Epitopes of South African Serotype 2 Foot-and-Mouth Disease Virus Elicits Specific Humoral and Cellular Responses in Mice.(Viruses, IF=4.7)
發(fā)表時間:2024/4/17
作者:Li Q, Ma X, Shen Y, et al.
作者單位:中國農(nóng)業(yè)科學(xué)院蘭州大學(xué)動物醫(yī)學(xué)院
使用產(chǎn)品:Mouse IL-2, IL-4 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38675963/
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27.?Mesenchymal Stem Cell-Derived Exosomes Attenuate Murine Cytomegalovirus-Infected Pneumonia via NF-κB/NLRP3 Signaling Pathway.(Viruses, IF=4.7)
發(fā)表時間:2024/4/16
作者:Chen F, Chen Z, Wu H T, et al.
作者單位:廣州醫(yī)科大學(xué)藥學(xué)院及基礎(chǔ)醫(yī)學(xué)院附屬第六醫(yī)院
使用產(chǎn)品:Muose TNF-α, IL-10, IL-1β and MCP-1 ELISA kits
樣本類型:肺組織
https://pubmed.ncbi.nlm.nih.gov/38675960/
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28.?Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membrane-decorated nanoparticles.(Acta Pharmaceutica Sinica B, IF=4.6)
發(fā)表時間:2024/4/23
作者:Zhang W, Zhai Y, Cai Y, et al.
作者單位:中國醫(yī)藥工業(yè)科學(xué)研究院
使用產(chǎn)品:Mouse IL-8, IL-6, GM-CSF, IL-12p40, MCP-1, IFN-α and IFN-β ELISA kits
https://www.sciencedirect.com/science/article/pii/S2211383524001382
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29.?Analyzing mechanisms of qing fei bao yuan decoction granules in treating COPD based on LC-MS, network pharmacology and in vivo methods.(Journal of Traditional and Complementary Medicine, IF=4.5)
發(fā)表時間:2024/4/14
作者:Tang A, Liu Y, Guan G, et al.
作者單位:貴州中醫(yī)藥大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Rat IL-1β, IL-6, TNF-ɑ, IL-8 and IL-17 ELISA kits
https://www.sciencedirect.com/science/article/pii/S2225411024000415
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30.?Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents.(RSC Medicinal Chemistry, IF=4.1)
發(fā)表時間:2024/4/23
作者:Wang Z, Zhang J, Gai C, et al.
作者單位:海軍軍醫(yī)大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-1β and TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlelanding/2024/md/d4md00053f/unauth
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31.?Identification of chalcone analogues as anti-inflammatory agents through the regulation of NF-κB and JNK activation.(RSC Medicinal Chemistry, IF=4.1)
發(fā)表時間:2024/4/5
作者:Zhang D, Wang W, Ou H, et al.
作者單位:云南中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://pubs.rsc.org/en/content/articlelanding/2024/md/d4md00011k
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32.?Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides.(RSC Advances , IF=3.9)
發(fā)表時間:2024/4/5
作者:Zhang X F, Du J X, Teng S Q, et al.
作者單位:中南民族大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38586440/
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33.?Elevated expression of NLRP3 promotes cigarette smoke-induced airway inflammation in chronic obstructive pulmonary disease.(Archives of Medical Science, IF=3.8)
發(fā)表時間:2024/4/25
作者:Wang M, Peng J, Yang M, et al.
作者單位:四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Mouse IL-1β and IL-18 ELISA kits
樣本類型:支氣管灌洗液
https://www.archivesofmedicalscience.com/Elevated-expression-of-NLRP3-promotes-cigarette-smoke-induced-airway-inflammation,176805,0,2.html#:~:text=NLRP3%20expression%20is%20elevated%20in%20lungs%20and%20sera,and%20their%20related%20inflammatory%20processes%20and%20signaling%20pathways.
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34.?Eriocitrin prevents Sepsis-induced acute kidney injury through anti-inflammation and anti-oxidation via modulating Nrf2/DRP1/OPA1 signaling pathway.(Biochimica et Biophysica Acta, IF=3.7)
發(fā)表時間:2024/4/19
作者:Wu M, Huang Z, Akuetteh P D P, et al.
作者單位:溫州醫(yī)科大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38642815/
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35.?Atractylodin ameliorates lipopolysaccharide-induced depressive-like behaviors in mice through reducing neuroinflammation and neuronal damage.(Journal of Neuroimmunology, IF=3.3)
發(fā)表時間:2024/4/23
作者:Liu F, Wang Y, Li D, et al.
作者單位:安康中心醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
樣本類型:海馬組織
https://pubmed.ncbi.nlm.nih.gov/38669915/
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36.?PLD2 deficiency alleviates endothelial glycocalyx degradation in LPS-induced ARDS/ALI.(Biochemical and Biophysical Research Communications, IF=3.1)
發(fā)表時間:2024/4/26
作者:Kong G, Li D, Liu X, et al.
作者單位:濱州醫(yī)學(xué)院附屬醫(yī)院
使用產(chǎn)品:Mouse IL-6, TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38703555/
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37.?Elabela mitigates the early stage of inflammation in sepsis by inhibiting pyroptosis.(American Journal of Translational Research, IF=2.2)
發(fā)表時間:2024/4/30
作者:Huang Y, Yu Y, Wang T, et al.
作者單位:南京醫(yī)科大學(xué)附屬淮安第一人民醫(yī)院
使用產(chǎn)品:Mouse IL-1β and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38715828/
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38.?Protection of Qingfei Xieding prescription from idiopathic pulmonary fibrosis by regulating renin-angiotensin and ferroptosis in MLE-12 cells.(Histology and Histopathology, IF=2)
發(fā)表時間:2024/4/10
作者:Sun L, He X, Kong J, et al.
作者單位:浙江大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-17 and TGF-β1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38666295/
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39.?Mechanism of sodium butyrate, a metabolite of gut microbiota, regulating cardiac fibroblast transdifferentiation via the NLRP3/Caspase-1 pyroptosis pathway.(Journal of Cardiothoracic Surgery, IF=1.6)
發(fā)表時間:2024/4/15
作者:Dong T, Huang D, Jin Z.
作者單位:溫州市中醫(yī)院
使用產(chǎn)品:Mouse IL-18 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38616256/
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40.?Efficacy and safety of the combination of paclitaxel, cisplatin and bevacizumab for the treatment of non-small cell lung cancer.(Tropical Journal of Pharmaceutical Research, IF=0.6)
發(fā)表時間:2024/4/30
作者:Zhang H, Fu L, Jiang J, et al.
作者單位:湖南省中醫(yī)研究院附屬醫(yī)院
使用產(chǎn)品:Human bFGF ELISA kit
extension://nhppiemcomgngbgdeffdgkhnkjlgpcdi/data/pdf.js/web/viewer.html?file=https://www.tjpr.org/admin/12389900798187/2024_23_4_13.pdf
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