乳酸(LA)的過量產(chǎn)生可能發(fā)生在運動期間或者許多疾病中,例如癌癥中。個人伴有高乳酸血癥的患者常表現(xiàn)為貧血、血清鐵減少以及一種鐵代謝關鍵調(diào)控因子—鐵調(diào)素(hepcidin)升高。然而,目前尚不清楚乳酸是否以及如何調(diào)節(jié)鐵調(diào)素的表達。最近,中國科學院生態(tài)環(huán)境科學研究中心在期刊《Cell Metabolism》(IF=29)上發(fā)表題為“Lactate modulates iron metabolism by binding soluble adenylyl cyclase.”的文章,展示乳酸與正常肝細胞中的可溶性腺苷酸環(huán)化酶(sAC)結(jié)合,并影響正常肝細胞中的全身鐵穩(wěn)態(tài) 上調(diào)小鼠鐵調(diào)素的表達。全面的體外、體內(nèi)和計算機實驗表明 LA-sAC相互作用提高了環(huán)磷酸腺苷(cAMP)水平,從而激活PKA-Smad1/5/8信號通路,增加鐵調(diào)素轉(zhuǎn)錄。同時在野生型小鼠和鐵穩(wěn)態(tài)紊亂的小鼠中驗證了這一調(diào)節(jié)軸。LA也調(diào)節(jié)人體靜息狀態(tài)下和經(jīng)受大量運動條件下的鐵調(diào)素。該研究將高乳酸血癥與缺鐵聯(lián)系起來,為運動員和乳酸酸中毒患者的貧血提供了一個全新的機制的闡述。
本文中使用了欣博盛Human IL-6(快速檢測) and CRP ELISA kit and Mouse IL-6 ELISA kit(快速檢測)檢測了血清樣本中目標蛋白的含量。
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1.文章題目:Lactate modulates iron metabolism by binding soluble adenylyl cyclase.
期 ???刊:Cell Metabolism(影響因子:29)
發(fā)表時間:21?July?2023
作 ???者:Liu W, Zhang S, Li Q, et al.
作者單位:中國科學院生態(tài)環(huán)境科學研究中心?
使用產(chǎn)品:Human IL-6(Quick Test) and CRP ELISA kit and Mouse IL-6 ELISA kit(Quick Test)
https://pubmed.ncbi.nlm.nih.gov/37480842/
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2.文章題目:Precisely Amplifying Intracellular Oxidative Storm by Metal–Organic Coordination Polymers to Augment Anticancer Immunity.
期 ???刊:ACS nano(影響因子:17.1)
發(fā)表時間:25?July?2023
作 ???者:Li S, Chen X, Guan S, et al.
作者單位:中國藥科大學?
使用產(chǎn)品:Mouse IL-6, IFN-γ, TNF-α and IL-12p70 ELISA kits
https://pubs.acs.org/doi/abs/10.1021/acsnano.3c04785
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3.文章題目:Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1.
期 ???刊:Nature Communications(影響因子:16.6)
發(fā)表時間:20?July?2023
作 ???者:Gao Y, Chi Y, Chen Y, et al.
作者單位:中國醫(yī)學科學院&北京協(xié)和醫(yī)科大學
使用產(chǎn)品:Human TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37474525/
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4.文章題目:A PDA‐Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy.
期 ???刊:Advanced Science(影響因子:15.1)
發(fā)表時間:9?July?2023
作 ???者:Zhang W, Chen Y, Li M, et al.
作者單位:河南科技大學第一附屬醫(yī)院?
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/37424037/
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5.文章題目:Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils.
期 ???刊:Acta Pharmaceutica Sinica B(影響因子:14.5)
發(fā)表時間:24?July?2023
作 ???者:Hua P, Liang R, Tu Y, et al.
作者單位:澳門大學?
使用產(chǎn)品:Rat TNF-α, IL-6 and IL-1β ELISA kits
https://www.sciencedirect.com/science/article/pii/S2211383523002836
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6.文章題目:Acetylation at the O-6 position of t-Glc improved immunoactivity of α-1, 6-glucan from longan by additionally activating Dectin-1 and CD14 receptors.
期 ???刊:Carbohydrate Polymers(影響因子:11.2)
發(fā)表時間:13?July?2023
作 ???者:Liu L, Lan H, Wang Y, et al.
作者單位:華南農(nóng)業(yè)大學
使用產(chǎn)品:Mouse IL-6, TNF-α and IL-10 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0144861723006641
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7.文章題目:Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter.
期 ???刊:Environmental Health Perspectives(影響因子:10.4)
發(fā)表時間:17?July?2023
作 ???者:Zhang R, Chen S, Wang Z, et al.
作者單位:中山大學?
使用產(chǎn)品:Mouse IL-17A, IL-1βand TGF-β ELISA kits
樣本類型:肺組織
https://pubmed.ncbi.nlm.nih.gov/37458712/
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8.文章題目:Platelet-derived exosomes hybrid liposomes facilitate uninterrupted singlet oxygen generation to enhance breast cancer immunotherapy.
期 ???刊:Cell Reports Physical Science(影響因子:8.9)
發(fā)表時間:19?July?2023
作 ???者:Ning S, Zhang X, Suo M, et al.
作者單位:廣西醫(yī)科大學?
使用產(chǎn)品:Mouse IFN-γ and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S2666386423002898.
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9.文章題目:T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity.
期 ???刊:Cell Reports(影響因子:8.8)
發(fā)表時間:15?July?2023
作 ???者:Cui Y, Yuan T, Wang Y, et al.
作者單位:中國科學院廣州生物醫(yī)藥與健康研究院?
使用產(chǎn)品:Human IgG(Total) ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37436890/
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10.文章題目:Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
期 ???刊:Journal of Pharmaceutical Analysis(影響因子:8.8)
發(fā)表時間:17?July?2023
作 ???者:Linghu K G, Zhang T, Zhang G T, et al.
作者單位:澳門大學?
使用產(chǎn)品:Mouse IL-6, IL-8, MCP-1, and IFN-γ ELISA kits
https://www.sciencedirect.com/science/article/pii/S209517792300148X
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11.文章題目:A frog peptide provides new strategies for the intervention against skin wound healing.
期 ???刊:Cellular & Molecular Biology Letters(影響因子:8.3)
發(fā)表時間:28?July?2023
作 ???者:Li C, Fu Z, Jin T, et al.
作者單位:昆明醫(yī)科大學?
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37501100/
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12.文章題目:The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism.
期 ???刊:International Journal of Biological Macromolecules(影響因子:8.2)
發(fā)表時間:1 July?2023
作 ???者:Shu Y, Huang Y, Dong W, et al.
作者單位:南京農(nóng)業(yè)大學
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37399869/
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13.文章題目:Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia.
期 ???刊:Journal of Translational Medicine(影響因子:7.4)
發(fā)表時間:28?July?2023
作 ???者:Zhou J, Zhao Y, An P, et al.
作者單位:復旦大學?
使用產(chǎn)品:Mouse TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37507742/
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14.文章題目:20 (S)‐Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis.
期 ???刊:Phytotherapy Research(影響因子:7.2)
發(fā)表時間:9?July?2023
作 ???者:Chen J, Lu P, Liu J, et al.
作者單位:澳門大學?
使用產(chǎn)品:Mouse/Human TNF-α, IL-1β, IL-18 and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37424151/
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15.文章題目:Cryptotanshinone alleviates radiation‐induced lung fibrosis via modulation of gut microbiota and bile acid metabolism.
期 ???刊:Phytotherapy Research(影響因子:7.2)
發(fā)表時間:10?July?2023
作 ???者:Li Z, Shen Y, Xin J, et al.
作者單位:廣東藥科大學?
使用產(chǎn)品:Mouse IL-6, IL-1β and TNF-α ELISA kits
樣本樣本:肺組織
https://pubmed.ncbi.nlm.nih.gov/37427974/
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16.文章題目:Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation.
期 ???刊:European Journal of Medicinal Chemistry(影響因子:6.7)
發(fā)表時間:18?July?2023
作 ???者:Huang J, Ma Z, Yang Z, et al.
作者單位:南方醫(yī)科大學藥學院?
使用產(chǎn)品:Mouse IL-1β and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37487306/
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17.文章題目:Therapeutic effects against high-grade glioblastoma mediated by engineered induced neural stem cells combined with GD2-specific CAR-NK.
期 ???刊:Cellular Oncology(影響因子:6.6)??
發(fā)表時間:7?July?2023
作 ???者:Liu W, Zhao Y, Liu Z, et al.
作者單位:首都醫(yī)科大學?
使用產(chǎn)品:Human IFN-γ and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37420122/?
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18.文章題目:Drug-Embedded Nanovesicles Assembled from Peptide-Decorated Hyaluronic Acid for Rheumatoid Arthritis Synergistic Therapy.
期 ???刊:Biomacromolecules(影響因子:6.2)
發(fā)表時間:7?July?2023
作 ???者:Hu Q, Zhang F, Wei Y, et al.
作者單位:四川大學華西醫(yī)院?
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37417966/
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19.文章題目:A biodegradable hollow nanoagent enables a boosted chemodynamic therapy by simultaneous autophagy inhibition and macrophage reeducation.
期 ???刊:International Journal of Pharmaceutics(影響因子:5.8)
發(fā)表時間:17?July?2023
作 ???者:Zhu H, Gao X, Wang B, et al.
作者單位:河北大學?
使用產(chǎn)品:Mouse TNF-α, IL-10, and IL-12p40 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37467817/
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20.文章題目:Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages.
期 ???刊:Molecular Medicine(影響因子:5.7)
發(fā)表時間:24?July?2023
作 ???者:Wang Y, Wan R, Hu C.
作者單位:中南大學湘雅醫(yī)院?
使用產(chǎn)品:Human Leptin ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37488474/
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21.文章題目:Suppression of TLR4 prevents diabetic bone loss by regulating FTO-mediated m6A modification.
期 ???刊:International Immunopharmacology(影響因子:5.6)
發(fā)表時間:4?July?2023
作 ???者:Shen X, Lan C, Lin Y, et al.
作者單位:福建醫(yī)科大學?
使用產(chǎn)品:Rat insulin ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37413932/
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22.文章題目:The ratio of total IgE level at week 16 to baseline significantly correlated with the clinical response to omalizumab in moderate to severe allergic rhinitis patients.
期 ???刊:International Immunopharmacology(影響因子:5.6)??
發(fā)表時間:11?July?2023
作 ???者:Zhao Z, Deng Y, Xiang L, et al.
作者單位:武漢大學人民醫(yī)院
使用產(chǎn)品:Anti mouse IgG-HRP
https://pubmed.ncbi.nlm.nih.gov/37441810/
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23.文章題目:Hypoxic postconditioning drives protective microglial responses and ameliorates white matter injury after ischemic stroke.
期 ???刊:CNS Neuroscience & Therapeutics(影響因子:5.5)??
發(fā)表時間:12?July?2023
作 ???者:Zhang W, Li S, Yun H J, et al.
作者單位:首都醫(yī)科大學?
使用產(chǎn)品:Mouse IL-1β, IL-10 and TGF-β1 ELISA kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/37435771/?
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24.文章題目:?Garcimultiflins A–C, unusual polycyclic polyprenylated acylphloroglucinols from the pericarps of Garcinia multiflora as interleukin-1β and pyroptosis inhibitors.
期 ???刊:Organic Chemistry Frontiers(影響因子:5.4)
發(fā)表時間:17?July?2023
作 ???者:Cao J, Chen J, Du R, et al.
作者單位:澳門大學?
使用產(chǎn)品:Mouse IL-1β and TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlelanding/2023/qo/d3qo00752a/unauth
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25.文章題目:Pyroptosis by NLRP3/caspase‐1/gasdermin‐D pathway in synovial tissues of rheumatoid arthritis patients.
期 ???刊:Journal of Cellular and Molecular Medicine(影響因子:5.3)??
發(fā)表時間:1 July?2023
作 ???者:Zhang X, Wang Q, Cao G, et al.
作者單位:洛陽骨科醫(yī)院?
使用產(chǎn)品:Human IL-1β and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37386795/
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26.文章題目:MALAT1/miR‐185‐5p mediated high glucose‐induced oxidative stress, mitochondrial injury and cardiomyocyte apoptosis via the RhoA/ROCK pathway.
期 ???刊:Journal of Cellular and Molecular Medicine(影響因子:5.3)??
發(fā)表時間:3?July?2023
作 ???者:Wang T, Li N, Yuan L, et al.
作者單位:河北醫(yī)科大學?
使用產(chǎn)品:Annexin V-FITC/PI detection Kit
https://pubmed.ncbi.nlm.nih.gov/37395157/
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27.文章題目:Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways.
期 ???刊:Biochimica et Biophysica Acta (BBA)-Molecular Cell Research(影響因子:5.1)
發(fā)表時間:17?July?2023
作 ???者:Zheng X Q, Kong X Q, He Y, et al.
作者單位:廈門大學醫(yī)學院?
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37468070/
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28.文章題目:Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression.
期 ???刊:Arthritis Research & Therapy(影響因子:4.9)
發(fā)表時間:19?July?2023
作 ???者:Lv L, Jiang H, Song D, et al.
作者單位:川北醫(yī)學院?
使用產(chǎn)品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37468929/
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29.文章題目:Semen Ziziphus jujube Saponins Protects HaCaT Cells against UV Damage and Alleviates the Aging of Caenorhabditis elegans.
期 ???刊:ACS Omega(影響因子:4.1)
發(fā)表時間:25?July?2023
作 ???者:Hao K X, Xie H, Jiang J G, et al.
作者單位:華南理工大學?
使用產(chǎn)品:Human MMP-1 ELISA?kit
https://pubs.acs.org/doi/full/10.1021/acsomega.3c00433
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30.文章題目:Jing-Fang powder ethyl acetate extracts attenuate atopic dermatitis by modulating T-cell activity.?
期 ???刊:Molecular Immunology(影響因子:3.6)?
發(fā)表時間:8?July?2023?
作 ???者:Zhao G, Tong Y, Xu J, et al. ?
作者單位:成都中醫(yī)藥大學
使用產(chǎn)品:Human IL-2 and IFN-γ ELISA kits?
https://pubmed.ncbi.nlm.nih.gov/37429064/
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31.文章題目:Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3× Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway.
期 ???刊:Journal of Dairy Science(影響因子:3.5)
發(fā)表時間:4?July?2023
作 ???者:Li Y, Zhang Z H, Huang S L, et al.
作者單位:深圳大學?
使用產(chǎn)品:Mouse IFN-γ, IL-1β, IL-6, TNF-α, IL-4 and IL-10 ELISA kits
樣本類型:大腦皮層勻漿
https://pubmed.ncbi.nlm.nih.gov/37414601/
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32.文章題目:Improvement of hemodynamics in mesenteric microcirculationin septic shock rats by anisodamine and anisodine.
期 ???刊:Mechanobiology in Medicine(影響因子:3.5)??
發(fā)表時間:5?July?2023
作 ???者:Zhong J, Ouyang Z, Shen J, et al.
作者單位:四川大學?
使用產(chǎn)品:Rat IL-6 and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S2949907023000062
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33.文章題目:Hepatoprotective effect of total flavonoids from Carthamus tinctorius L. leaves against carbon tetrachloride-induced chronic liver injury in mice.
期 ???刊:Fitoterapia(影響因子:3.4)
發(fā)表時間:10?July?2023
作 ???者:Ma M, Chen L, Tang Z, et al.
作者單位:陜西中醫(yī)藥大學?
使用產(chǎn)品:Mouse IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37437698/
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34.文章題目:PDGF-BB/PDGFRβ induces tumour angiogenesis via enhancing PKM2 mediated by the PI3K/AKT pathway in Wilms’ tumour.
期 ???刊:Medical Oncology(影響因子:3.4)
發(fā)表時間:14?July?2023
作 ???者:Sang B, Wang C, Liu X, et al.
作者單位:重慶醫(yī)科大學?
使用產(chǎn)品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37442847/
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35.文章題目:Influences of lysine‐specific demethylase 1 inhibitors on NO synthase–Kruppel‐like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo.
期 ???刊:Journal of Applied Toxicology(影響因子:3.3)
發(fā)表時間:5?July?2023
作 ???者:Yuan J, Que R, Zhao W, et al.
作者單位:南華大學?
使用產(chǎn)品:Human IL-8 and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37408164/
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36.文章題目:Pro-angiogenic activity of salvianolate and its potential therapeutic effect against acute cerebral ischemia.
期 ???刊:Experimental and Therapeutic Medicine(影響因子:2.7)
發(fā)表時間:10?July?2023
作 ???者:Xu J, Shen Y, Luan P, et al.
作者單位:青島大學
使用產(chǎn)品:Mouse VEGF ELISA kits
https://www.spandidos-publications.com/10.3892/etm.2023.12108
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37.文章題目:Exercise Plus Acupuncture on Consensus Acupoints Versus Acupoints Selected by the Theory of Equal Impact on Tendons, Bones, and Muscles for Knee Osteoarthritis.
期 ???刊:Alternative Therapies in Health and Medicine(影響因子:1.5)
發(fā)表時間:29?July?2023
作 ???者:Wang Y.
作者單位:河北中醫(yī)藥大學?
使用產(chǎn)品:Human IL-1β?and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37052974/
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