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Amyloid Beta 1-42 Oligomers
品牌： Stressmarq
產(chǎn)品貨號(hào)： SPR-488B
規(guī)格： 100 μg

報(bào)價(jià)：
折后價(jià)：

數(shù)量： - +
產(chǎn)品詳情
* 以下信息僅供參考，詳情請(qǐng)以原廠網(wǎng)站為準(zhǔn)
  • 產(chǎn)品名稱:
    Amyloid Beta 1-42 Oligomers
  • 別名:
    Abeta Oligomers, Abeta peptide, Amyloid beta peptide oligomers, Beta amyloid peptide oligomers, amyloid beta precursor protein peptide oligomers, APP
  • 產(chǎn)品描述:
    Human Synthetic Amyloid Beta 1-42 Oligomers
  • 反應(yīng)種屬:
    Human
  • 宿主來源:
  • 實(shí)驗(yàn)應(yīng)用:
    WB | In vivo Assay | In vitro Assay
  • 靶標(biāo)/特異性:
  • 同種型:
  • 推薦稀釋度:
  • 免疫原:
  • 免疫原種屬:
  • 克隆性:
  • 克隆號(hào):
  • 純化方式:
    N/A
  • 偶聯(lián):
    No Tag
  • 產(chǎn)品濃度:
    1 mg/ml
  • 表達(dá)系統(tǒng):
    N/A
  • 陽(yáng)性對(duì)照:
  • 保存溫度:
    -80oC
  • 運(yùn)輸溫度:
    Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
  • 細(xì)胞定位:
  • 預(yù)期分子量:
    4.5 kDa
  • 產(chǎn)品形式:
  • 存儲(chǔ)溶液:
    Phosphate buffer (PB) pH 7.4 and 10 mM NaCl
  • 有效期:
  • 產(chǎn)地:
    加拿大
  • 外觀:
  • 生產(chǎn)商:
  • 功能與背景:
    Our Amyloid Beta 1-42 (Aβ42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (1,2). Our Aβ42 oligomers present as globular oligomers when observed under TEM and AFM, and have a unique dimer/trimer and oligomer signal on a Western Blot with an anti-amyloid beta antibody. Our Aβ42 oligomers were also demonstrated to be toxic to primary rat cortical neurons in a dose-dependent manner. In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Soluble Aβ oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function (4). Aβ oligomers generated in vitro were toxic to PC12 cells (5) and SH-SY5Y cells (6). Aβ was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients (7) and accumulations of Aβ were shown to be associated with lower survival rates in Parkinson’s disease patients with dementia (8).
  • URL:
  • 靈敏度:
  • 檢測(cè)范圍:
  • 檢測(cè)方法:
  • 樣本類型:
    Phosphate buffer (PB) pH 7.4 and 10 mM NaCl
  • 產(chǎn)品特點(diǎn):
  • 純度:
    >95%
  • 生物活性:
  • 內(nèi)毒素水平:
  • 來源:
  • 表達(dá)方式:
  • Accession #:
  • CAS號(hào):
  • 分子式:
  • 溶解度:
  • PubChem CID:
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