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Ganglioside GM1 . sodium salt (bovine brain)
品牌： Adipogen
產(chǎn)品貨號(hào)： AG-CN2-9000-M001
規(guī)格： 1 mg

報(bào)價(jià)：
折后價(jià)：

數(shù)量： - +
產(chǎn)品詳情
* 以下信息僅供參考，詳情請(qǐng)以原廠網(wǎng)站為準(zhǔn)
  • 產(chǎn)品名稱:
    Ganglioside GM1 . sodium salt (bovine brain)
  • 別名:
    GM1 . Na; Monosialoganglioside GM1 . Na
  • 產(chǎn)品描述:
    Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis and which is important for neuronal plasticity and repair mechanisms. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-kappaB and activation of dendritic cells. E. coli heat-labile enterotoxin (LT) is structurally and functionally similar to cholera toxin and binds GM1 as well. GM1 has also been shown to improve Parkinson's disease symptoms and slow it's progression.
  • 反應(yīng)種屬:
  • 宿主來(lái)源:
    Isolated from bovine brain.
  • 實(shí)驗(yàn)應(yīng)用:
  • 靶標(biāo)/特異性:
  • 同種型:
  • 推薦稀釋度:
  • 免疫原:
  • 免疫原種屬:
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  • 表達(dá)系統(tǒng):
  • 陽(yáng)性對(duì)照:
  • 保存溫度:
    -20°C
  • 運(yùn)輸溫度:
    Ambient
  • 細(xì)胞定位:
  • 預(yù)期分子量:
    1545.8 . 23.0 (calculated on sphingosine C18:1 and stearic acid)
  • 產(chǎn)品形式:
    solid
  • 存儲(chǔ)溶液:
    Lyophilized.
  • 有效期:
    Stable for at least 2 years after receipt when stored at -20°C.
  • 產(chǎn)地:
    瑞士
  • 外觀:
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  • 功能與背景:
  • URL:
  • 靈敏度:
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  • 樣本類型:
    Lyophilized.
  • 產(chǎn)品特點(diǎn):
  • 純度:
    >98% (TLC)
  • 生物活性:
  • 內(nèi)毒素水平:
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  • Accession #:
  • CAS號(hào):
    37758-47-7
  • 分子式:
    C73H130N3O31 . Na
  • 溶解度:
  • PubChem CID:
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