BioXcell新品推薦——InVivoMAb anti-mouse FasL (CD178)單克隆抗體

2021-04-29

瀏覽次數(shù)： 54

Fas配體(FasL)也稱為CD178，CD95配體或TNFSF6，是一種大小為40kDa的Ⅱ型跨膜糖蛋白，屬于TNF超家族的成員。FasL在活化的T細胞以及脾臟、睪丸和眼睛中表達。當它與受體CD95（Fas）結(jié)合時，FasL誘導(dǎo)凋亡細胞死亡以維持外周耐受性。有些腫瘤過度表達FasL并誘導(dǎo)浸潤淋巴細胞凋亡，使腫瘤逃避免疫反應(yīng)的影響。CD178/CD95的相互作用也被認為在CD8+細胞增殖和中性粒細胞外滲、趨化和存活中起作用。據(jù)報道，MFL3抗體可阻斷CD178/CD95誘導(dǎo)的細胞凋亡。

產(chǎn)品信息：

產(chǎn)品貨號	BE0319
產(chǎn)品名稱	InVivoMAb?anti-mouse?FasL?(CD178)
規(guī)格	1mg,5mg,25mg,?50mg,?100mg
克隆號	MFL3
同種型(Isotype)	Armenian?Hamster?IgG
免疫原(Immunogen)	BHK?cells?expressing?B6?mouse?FasL
成分(Formulation)	PBS,?pH?7.0??
	Contains?no?stabilizers?or?preservatives
內(nèi)毒素(Endotoxin)	<2EU/mg?(<0.002EU/μg)
	Determined?by?LAL?gel?clotting?assay
純度(Purity)	>95%
	Determined?by?SDS-PAGE
無菌(Sterility)	0.2?μM?filtered
生產(chǎn)(Production)	Purified?from?tissue?culture?supernatant?in?an?animal?free?facility
純化(Purification)	Protein?A
保存(Storage)	Undiluted?at?4°C?in?the?dark
應(yīng)用(Reported?Applications)	in?vivo?FasL?blockade
	In?vitro?FasL?blockade
	Functional?assay
	Immunohistochemistry?(paraffin)
	Flow?Cytometry

Application References:

Lakins, M. A., et al. (2018). 'Cancer-associated fibroblasts induce antigen-specific deletion of CD8 (+) T Cells to protect tumour cells.'?Nat Commun?9(1): 948.?PubMed

Lotti, R., et al. (2018). 'Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus.'?Front Immunol?9: 370.?PubMed

Bien, K., et al. (2017). 'Involvement of Fas/FasL pathway in the murine model of atopic dermatitis.'?Inflamm Res?66(8): 679-690.?PubMed

D'Aloia, M. M., et al. (2016). 'T lymphocytes engineered to express a CD16-chimeric antigen receptor redirect T-cell immune responses against immunoglobulin G-opsonized target cells.'?Cytotherapy?18(2): 278-290.?PubMed

Linkermann, A., et al. (2011). 'Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure.'?Kidney Int?79(2): 169-178.?PubMed

Kayagaki, N., et al. (1997). 'Polymorphism of murine Fas ligand that affects the biological activity.'?Proc Natl Acad Sci U S A?94(8): 3914-3919.?PubMed

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