ENZO熱銷產(chǎn)品——Leptin (mouse), ELISA kit

2023-06-02

瀏覽次數(shù)： 46

瘦素(Leptin)是由ob基因編碼、在脂肪組織中生成的一種脂肪代謝調(diào)控產(chǎn)物，在代謝和調(diào)控體重等方面發(fā)揮重要作用。它通過下丘腦中的瘦素受體發(fā)出信號，降低食欲，增加能量消耗。在外周組織中，瘦素能拮抗胰島素信號傳導(dǎo)，增加脂肪酸氧化，減少胰島β細(xì)胞的胰島素分泌，并促進(jìn)生育。它在脂肪細(xì)胞中的表達(dá)可以被其他脂肪因子如IL-6（刺激）和TNF-α（抑制）以旁分泌方式調(diào)節(jié)。瘦素缺乏的小鼠表現(xiàn)出嚴(yán)重的胰島素抵抗、肥胖和生育能力下降，所有這些都可以通過外源性瘦素給藥而逆轉(zhuǎn)。還有研究表明，瘦素與心血管疾病有關(guān)，因為它介導(dǎo)了許多促炎和促動脈粥樣硬化作用，如內(nèi)皮素-1（ET-1）表達(dá)增加、活性氧（ROS）積累、單核細(xì)胞趨化蛋白-1（MCP-1）分泌以及交感血管張力和血壓增加。

●?靈活：適用于正常和病理樣本

●?高靈敏：可檢測<26 pg/ml的小鼠瘦素水平

●?快速：僅需3小時就可獲得39個樣本的重復(fù)結(jié)果

●?方便：預(yù)包被板和即用型試劑為您節(jié)省實驗時間

ENZO熱銷產(chǎn)品——Leptin (mouse), ELISA kit ?

產(chǎn)品信息

產(chǎn)品貨號	ADI-900-019A
產(chǎn)品名稱	Leptin (mouse), ELISA kit（小鼠瘦素ELISA試劑盒）
規(guī)格	96 wells
靈敏度	25.4 pg/ml
檢測范圍	50-3,200 pg/ml
檢測時間	3 hours
樣本種屬	Mouse
樣本類型	culture supernatants, plasma, and serum.? Cited sample type includes tissue
保存溫度	+4°C
試劑盒組分	Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 28,? TMB Substrate, Stop solution 2, Wash buffer concentrate

部分產(chǎn)品引用文獻(xiàn)

1. High salt diet does not impact the development of acute myeloid leukemia in mice: M. Janakiraman, et al.; Cancer Immunol. Immunother. 72, 265 (2023)

2. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress: L. Morató, et al.; Sci. Adv. 8, eabj9109 (2022)?

3. Transcription factor CREB3 is a potent regulator of high-fat diet-induced obesity and energy metabolism: B.S. Smith, et al.; Int. J. Obes. 46, 1446 (2022)

4. The effects of mirabegron on obesity-induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue: C. Peres Valgas da Silva, et al.; Clin. Exp. Pharmacol. Physiol. 48, 1477 (2021)

5. Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism: M. Woo, et al.; Mar. Drugs 16, 306 (2018)?

6. Anti-obesity effects of pectinase and cellulase enzyme?treated Ecklonia cava extract in high?fat diet?fed C57BL/6N mice: I.H. Kim, et al.; Int. J. Mol. Med. 41, 924 (2018), Application(s): ELISA using mouse serum?

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