Clozapine N-oxide? BML-NS105 ?

氯氮平主要代謝物

純度≥99% (HPLC)，適用于體內(nèi)和體外實(shí)驗(yàn)。

外觀：黃色固體

可溶性：可溶于水，溶解度為5mg/ml。

穩(wěn)定性：液體-20度能夠保持4個(gè)月。

參考文獻(xiàn)：

Activation and inhibition of transient receptor potential TRPM3-induced gene transcription: A. Lesch, et al. ; Br. J. Pharmacol.171, 2645 (2014),?Abstract;

Chemogenetic silencing of neurons in retrosplenial cortex disrupts sensory preconditioning: S. Robinson, et al.; J. Neurosci.?34, 10982 (2014),?Abstract;

CREB Regulates Memory Allocation in the Insular Cortex: Y. Sano, et al.; Curr. Biol.?24, 2833 (2014),?Abstract;

Cyclin-Dependent Kinase 5 in the Ventral Tegmental Area Regulates Depression-Related Behaviors: P. Zhong, et al.; J. Neurosci.?34, 6352 (2014),?Abstract;?Full Text

Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition: F. Yi, et al.; J. Physiol.?592, 3463 (2014),?Abstract;

Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures: F. Yi, et al.; Epilepsia (2014),?Abstract;

Regulation of immediate-early gene transcription following activation of Gα(q)-coupled designer receptors: A. Kaufmann, et al.; J. Cell. Biochem.?114, 681 (2013),?Abstract;

Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL): E. Alvarez-Curto, et al.; Mol. Pharmacol.?80, 1033 (2011),?Abstract;?Full Text

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One?6, e25395 (2011),?Abstract;?Full Text

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors: B.L. Roth, et al.; J. Pharmacol. Exp. Ther.?268, 1403 (1994),?Abstract;

Decomposition of clozapine N-oxide in the qualitative and quantitative analysis of clozapine and its metabolites: G. Lin, etal.; J. Pharm. Sci.?83, 1412 (1994),?Abstract;