CDS可識(shí)別受損的、定位錯(cuò)誤的、或致病性DNA，進(jìn)而通過TBK1-IRF3通路誘導(dǎo)I型干擾素的產(chǎn)生。DNA通常定位于細(xì)胞核或線粒體中，但當(dāng)它的合成或運(yùn)輸出現(xiàn)錯(cuò)誤時(shí)會(huì)在細(xì)胞漿中聚集。此外，在感染情況下，病毒或微生物的DNA也可以進(jìn)入到宿主細(xì)胞的細(xì)胞漿中。許多CDS已經(jīng)被報(bào)道，包括腺苷脫氨酶DAI、解旋酶DDX41、干擾素誘導(dǎo)的IF116蛋白，以及cGAS(環(huán)-GMP-AMP合成酶)。AIM2是另外一種胞漿脫氧核糖核酸傳感器，它受到刺激后形成炎癥小體并進(jìn)一步誘導(dǎo)產(chǎn)生IL-1?。
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PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
CDS Agonists |
ODN TTAGGG (A151) | Inhibitory ODN, human preferred | TLR2 -/ TLR4 - | 100 nM - 10 μM | 200 μg 1 mg | tlrl-ttag151 tlrl-ttag151-1 |
dsDNA-EC | E. coli K12 genomic DNA | TLR2 -/ TLR4 - | 30 ng - 1 μg/ml | 200 μg | tlrl-ecdna |
G3-YSD????????????????????????????????????? NEW | Y-form DNA | TLR2 -/ TLR4 - | 100 ng - 1 μg/ml | 200 μg | tlrl-ydna |
G3-YSD Control?????????????????? NEW | Control for Y-form DNA | TLR2 -/ TLR4 - | 100 ng - 1 μg/ml | 200 μg | tlrl-ydnac |
HSV-60 Naked | HSV1-derived 60 bp oligonucleotide | TLR2 -/ TLR4 - | 30 ng - 10 μg/ml | 200 μg | tlrl-hsv60n |
HSV-60 LyoVec? | Precomplexed HSV1-derived 60 bp ODN | TLR2 -/ TLR4 - | 300 ng - 10 μg/ml | 100 μg | tlrl-hsv60c |
HSV-60c Naked | Control for HSV-60 ODN | TLR2 -/ TLR4 - | 30 ng - 10 μg/ml | 200 μg | tlrl-hsv60cn |
HSV-60c/LyoVec? | Precomplexed control for HSV-60 ODN | TLR2 -/ TLR4 - | 300 ng - 10 μg/ml | 100 μg | tlrl-hsv60cc |
ISD Naked | Interferon stimulatory DNA | TLR2 -/ TLR4 - | 100 ng - 10 μg/ml | 200 μg | tlrl-isdn |
ISD/LyoVec? | Precomplexed interferon stimulatory DNA | TLR2 -/ TLR4 - | 300 ng - 10 μg/ml | 100 μg | tlrl-isdc |
ISD Control Naked | Non-immunostimulatory ODN | TLR2 -/ TLR4 - | 100 ng - 10 μg/ml | 200 μg | tlrl-isdcn |
ISD Control/LyoVec? | Precomplexed non-immunostimulatory ODN | TLR2 -/ TLR4 - | 300 ng - 10 μg/ml | 100 μg | tlrl-isdcc |
Poly(dA:dT) Naked | Poly(dA-dT)?poly(dT-dA) | TLR2 -/ TLR4 - | 1 - 5 μg/ml | 200 μg 1 mg | tlrl-patn tlrl-patn-1 |
Poly(dA:dT)/LyoVec? | Poly(dA-dT)?poly(dT-dA)/LyoVec? complexes | TLR2 -/ TLR4 - | 1 - 5 μg/ml | 100 μg | tlrl-patc |
Poly(dA:dT)/Rhodamine | Rhodamine labeled poly(dA-dT)?poly(dT-dA) | TLR2 -/ TLR4 - | 30 ng - 10 μg/ml | 10 μg | tlrl-patrh |
Poly(dG:dC) Naked | Poly(dG-dC)?poly(dG-dC) | TLR2 -/ TLR4 - | 10 ng - 10 μg/ml | 200 μg | tlrl-pgcn |
Poly(dG:dC)/LyoVec? | Poly(dG-dC)?poly(dG-dC)/LyoVec? complexes | TLR2 -/ TLR4 - | 10 ng - 10 μg/ml | 100 μg | tlrl-pgcc |
VACV-70 Naked | Vaccinia virus-derived 70 bp oligonucleotide | TLR2 -/ TLR4 - | 30 ng - 10 μg/ml | 200 μg | tlrl-vav70n |
VACV-70/LyoVec? | Precomplexed vaccinia virus-derived 70 bp ODN | TLR2 -/ TLR4 - | 300 ng - 10 μg/ml | 100 μg | tlrl-vav70c |
VACV-70c Naked | Control for VACV-70 ODN | TLR2 -/ TLR4 - | 30 ng - 10 μg/ml | 200 μg | tlrl-vav70cn |
VACV-70c/LyoVec? | Precomplexed control for VACV-70 ODN | TLR2 -/ TLR4 - | 300 ng - 10 μg/ml | 100 μg | tlrl-vav70cc |
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