Mincle是一個(gè)多功能的危險(xiǎn)信號(hào)感知分子，可識(shí)別一系列配體，包括受損的細(xì)胞、真菌、酵母和結(jié)合分枝桿菌。Mincle的胞外配體包括真菌的α-mannose(甘露糖)、分枝桿菌的糖脂和來(lái)自結(jié)核分枝桿菌具有免疫刺激功能的TDM(trehalose-6’6’-dimycolate)組分。此外，Mincle還可通過(guò)識(shí)別其內(nèi)源的DAMP來(lái)感知受損的細(xì)胞。SAP130(剪接體相關(guān)蛋白130)是已被發(fā)現(xiàn)的DAMP之一，它是一種由壞死細(xì)胞釋放的可溶性因子。Mincle通過(guò)Syk激酶?jìng)鬟f信號(hào)，透過(guò)CARD9來(lái)激活NF-κB。Syk還可引起胞內(nèi)的鈣動(dòng)員和calcineurin-NFAT信號(hào)通路的活化。
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PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
Mincle Agonists |
GlcC14C18????????? ???????????????????????????????????????NEW | Glucosyl-6-tetradecyloctadecanoate | TLR2 -/ TLR4 - | 10 ng - 1 μg/ml | 2 mg | tlrl-gcc |
HKMT | Heat Killed Mycobacterium tuberculosis | TLR2 +/ TRL4 - | 10 - 100 μg/ml | 10 mg 50 mg | tlrl-hkmt-1 tlrl-hkmt-5 |
TDB | Synthetic analog of the cord factor | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 2 mg | tlrl-tdb |
TDB VacciGrade? | Preclinical grade TDB | VacciGrade? | 1 - 100 μg/mouse | 2 mg | vac-tdb |
TDB-HS15 | Formulated TDB | TLR2 -/ TLR4 - | 0.3 - 100 μg/ml | 2 mg | tlrl-stdb |
TDM???????????????????????????????????????????????????????????? NEW | Trehalose-6,6-dimycolate; also known as cord factor | TLR2 -/ TLR4 - | 300 ng-10 μg/ml | 2 mg | tlrl-tdm |
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