Dectin-1是C型凝集素受體(CLR)家族成員之一，在抗真菌天然免疫反應(yīng)中發(fā)揮重要作用。Dectin-1是β-glucan(β-葡聚糖)的特異性跨膜受體。β-glucan，即葡萄糖聚合物，則是真菌(包括釀酒酵母Saccharomyces cerevisiae和白色念珠球菌Candida albican)細(xì)胞壁的主要成分。與其受體結(jié)合后，Dectin-1會(huì)引起細(xì)胞胞吞作用，并通過(guò)Syk激酶和接頭分子CARD9/Bcl10/Malt1傳遞信號(hào)，進(jìn)而誘導(dǎo)活性氧ROS的產(chǎn)生、NF-κB的活化及后續(xù)炎癥因子的產(chǎn)生。Dectin-1和TLR2可協(xié)同發(fā)揮作用來(lái)增強(qiáng)各自的信號(hào)級(jí)聯(lián)反應(yīng)。
相關(guān)產(chǎn)品推薦：
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
Dectin-1 Agonists |
Beta-Glucan Peptide | Beta-glucan from?Trametes versicolor | TLR2 -/ TLR4 - | 1 - 100?μg/ml | 50 mg | tlrl-bgp |
Curdlan | Beta-1,3-glucan from?Alcaligenes faecalis | TLR2 -/ TLR4 - | 100?μg/ml | 1 g | tlrl-curd |
HKCA | Heat-killed?Candida albicans | TLR2 -/ TLR4 - | 108?cells/ml | 109?cells | tlrl-hkca |
Laminarin | Soluble beta-glucan from?Laminaria digitata | TLR2 +/ TLR4 - | 1 - 100?μg/ml | 100 mg | tlrl-lam |
Pustulan | Beta-glucan from?Lasallia pustulata | TLR2 -/ TLR4 - | 1 - 100?μg/ml | 100 mg | tlrl-pst |
Schizophyllan | Beta-glucan from?Schizophyllum commune | TLR2 -/ TLR4 - | 1 - 100?μg/ml | 100 mg | tlrl-spg |
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
Dectin-1 Agonists |
Scleroglucan | Beta-glucan from?Sclerotium rolfsii | TLR2 +/ TLR4 + | 1 - 100?μg/ml | 100 mg | tlrl-scg |
WGP Dispersible | Whole Glucan Particles, insoluble | TLR2 -/ TLR4 - | 1 - 200?μg/ml | 50 mg | tlrl-wgp |
WGP Soluble | Whole Glucan Particles, soluble | TLR2 -/ TLR4 - | 1 ng - 1?μg/ml | 50 mg | tlrl-wgps |
Zymosan | Cell wall preparation from?S. cerevisiae | TLR2 +/ TLR4 - | 1 - 10?μg/ml | 100 mg | tlrl-zyn |
Zymosan Depleted | Hot alkali treated zymosan | TLR2 -/ TLR4 - | 100?μg/ml | 10 mg | tlrl-zyd |
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